Functional expression of Cre recombinase in sub-regions of mouse CNS and retina
Functional expression of Cre recombinase in sub-regions of mouse CNS and retina
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DOI：
10.1016/s0014-5793(00)01893-7
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发表时间：
2000-08-18
期刊：
影响因子：
3.5
通讯作者：
Holmberg, D
中科院分区：
文献类型：
--
作者：
Eriksson, B;Bergqvist, I;Holmberg, D
我们描述了一种使用Cre/loxP系统产生CNS和视网膜亚区域特异性突变的策略。建立了在c-kit启动子控制下表达Cre重组酶的转基因小鼠。功能性Cre表达主要被发现限于海马的CA 1、CA 2和CA 3区域、齿状回的前部区域和视网膜的神经节细胞层。(C)2000年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
We describe a strategy for generating CNS and retina sub-region-specific mutations using the Cre/loxP system. Transgenic mice expressing Cre recombinase under the control of the c-kit promoter were established. Functional Cre expression was predominantly found to be restricted to the CA1, CA2 and CA3 regions of the hippocampus, the anterior region of the dentate gyrus, and to the ganglion cell layer of the retina. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.