A Study of The Clinical Viability of A Prototype Compton Camera for Prompt Gamma Imaging Based Proton Beam Range Verification
A Study of The Clinical Viability of A Prototype Compton Camera for Prompt Gamma Imaging Based Proton Beam Range Verification
复制标题
基于快速伽玛成像的质子束射程验证原型康普顿相机的临床可行性研究
DOI：
--
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
M. Gobbert
中科院分区：
文献类型：
--
作者：
J. Polf;C. Barajas;Gerson C. Kroiz;S. Peterson;P. Maggi;D. Mackin;S. Beddar;M. Gobbert
我们提出康普顿相机（CC）为基础的PG成像质子范围验证在临床剂量率。在临床质子束照射下，用原型CC测量了组织等效幻体的PG发射，并对原始测量数据和经过训练的神经网络（NN）处理的数据进行了图像重建，以识别“真实”和“虚假”PG事件。从这些图像中，我们确定由原型CC产生的PG图像是否可以提供有关质子束放疗期间所传递的质子束体内范围的临床有用信息。发现对数据进行神经网络处理是必要的，可以从PG图像中识别质子束路径。此外，为了使原型CC能够以≤3mm的精度定位质子束范围的末端，需要输送~1 x 109个质子，这是标准质子放疗治疗场输送的数量级。为了获得更高的光束范围确定精度，并允许在整个治疗区域内对单个质子铅笔束进行成像，需要进一步提高CC， NN数据处理和图像重建算法的PG检测率。
We present Compton camera (CC) based PG imaging for proton range verification at clinical dose rates. PG emission from a tissue-equivalent phantom during irradiation with clinical proton beams was measured with a prototype CC. Images were reconstructed of the raw measured data and of data processed with a neural network (NN) trained to identify “true” and “false” PG events. From these images, we determine if PG images produced by the prototype CC could provide clinically useful information about the in vivo range of the proton beams delivered during proton beam radiotherapy. NN processing of the data was found necessary to allow identification of the proton beam path from the PG images. Furthermore, to allow the localization of the end of the proton beam range with a precision of ≤ 3mm with the prototype CC, ~1 x 109 protons would need to be delivered, which is on the order of magnitude delivered for a standard proton radiotherapy treatment field. To obtain higher precision in beam range determination and to allow imaging a single proton pencil beam delivered within the full treatment field, further improvements in PG detection rates by the CC, NN data processing, and image reconstruction algorithms are needed.
影响因子：
3.8
作者：
Parodi K;Polf JC
通讯作者：
Polf JC
DOI：
10.1002/pamm.202000070
发表时间：
2021-01
期刊：
PAMM
影响因子：
--
作者：
Jonathan N. Basalyga-;Carlos A. Barajas;M. Gobbert;P. Maggi;J. Polf
通讯作者：
Jonathan N. Basalyga-;Carlos A. Barajas;M. Gobbert;P. Maggi;J. Polf