Expansion of sensorimotor cortical activation for unilateral hand motion during contralateral hand deafferentation
Expansion of sensorimotor cortical activation for unilateral hand motion during contralateral hand deafferentation
复制标题
对侧手传入阻滞期间单侧手运动的感觉运动皮层激活的扩展
DOI：
10.1097/wnr.0000000000000138
复制
发表时间：
2014
期刊：
影响因子：
1.7
通讯作者：
Fujii Y
中科院分区：
文献类型：
--
作者：
Kurabe S;Itoh K;Matsuzawa H;Nakada T;Fujii Y
急性剥夺单侧感觉输入可迅速增强对侧手的运动功能，但其潜在机制尚不清楚。在此，我们使用功能磁共振成像技术评估了14名健康人在可逆性、非侵入性缺血性神经阻滞(INB)诱导的左前臂感觉剥夺前、中、后右指运动皮质的激活情况。在INB前，运动任务如预期那样激活左侧初级感觉运动皮质(SM1)。INB期间，左侧SM1的激活量显著增加，INB后恢复到INB前的基线水平。通过确认右侧初级感觉皮质中通常由左食指触觉刺激引起的激活消失，确保了左前臂INB的有效性。这些结果表明，单侧前臂的急性去传入导致对侧手指运动的神经基质发生快速和可逆的变化，这可能是通过减弱经颧骨半球间的抑制而起作用的。
Acute deprivation of unilateral sensory input rapidly enhances contralateral hand motor function, but the underlying mechanisms remain poorly understood. We herein used functional MRI to evaluate, in 14 healthy individuals, motor cortical activation for right finger motion before, during, and after sensory deprivation of left forearm induced by reversible, noninvasive ischemic nerve block (INB). Before INB, the motor task activated the left primary sensorimotor cortex (SM1) as expected. During INB, the volume of the left SM1 activation significantly increased, and, after INB, it returned to the pre-INB, baseline level. The effectiveness of the INB of the left forearm was ensured by confirming disappearance of the activation in right primary sensory cortex that is normally caused by tactile stimulation of the left index finger. These findings demonstrate that acute deafferentation of unilateral forearm causes rapid and reversible changes in the neural substrates for contralateral finger motion, mediated possibly by attenuation of transcallosal interhemispheric inhibition.