Poliovirus Excretion Among Persons With Primary Immune Deficiency Disorders: Summary of a Seven-Country Study Series
Poliovirus Excretion Among Persons With Primary Immune Deficiency Disorders: Summary of a Seven-Country Study Series
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DOI：
10.1093/infdis/jiu065
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发表时间：
2014-11-01
影响因子：
6.4
通讯作者：
Sutter, Roland W.
中科院分区：
文献类型：
--
作者：
Li, Li;Ivanova, Olga;Sutter, Roland W.
背景患有原发性免疫缺陷疾病的人，特别是那些影响B细胞系统的疾病，患麻痹性脊髓灰质炎的风险大大增加，并可长期排出脊髓灰质炎病毒。然而，在发展中国家，长期或慢性排泄的风险没有得到很好的描述。我们提出了一个国家的研究系列PIDcases.Methods之间的脊髓灰质炎病毒排泄的总结。aEuro积分例PID从参与机构在第一年入组，并在获得知情同意后，进行了测试的粪便样本中的脊髓灰质炎病毒。在第二年期间，对这些排出脊髓灰质炎病毒的病例进行每月随访，直到获得2份阴性粪便样本。结果。其中，17例（3%）散发脊髓灰质炎病毒，包括2例免疫缺陷疫苗衍生脊髓灰质炎病毒病例。在5/17例（29%）病例的单一样本中检出脊髓灰质炎病毒。1例排泄时间超过6个月。在研究期间，所有病例均未发生瘫痪。结论：即使在PID患者中，慢性脊髓灰质炎病毒排泄仍然是罕见事件。然而，由于这些人没有瘫痪，他们可能被当前的监测遗漏;因此，应在PID中建立脊髓灰质炎病毒监测。
Background. Persons with primary immune deficiency disorders (PID), especially those disorders affecting the B-cell system, are at substantially increased risk of paralytic poliomyelitis and can excrete poliovirus chronically. However, the risk of prolonged or chronic excretion is not well characterized in developing countries. We present a summary of a country study series on poliovirus excretion among PID cases.Methods.aEuro integral Cases with PID from participating institutions were enrolled during the first year and after obtaining informed consent were tested for polioviruses in stool samples. Those cases excreting poliovirus were followed on a monthly basis during the second year until 2 negative stool samples were obtained.Results.aEuro integral A total of 562 cases were enrolled in Bangladesh, China, Iran, Philippines, Russia, Sri Lanka, and Tunisia during 2008-2013. Of these, 17 (3%) shed poliovirus, including 2 cases with immunodeficient vaccine-derived poliovirus. Poliovirus was detected in a single sample from 5/17 (29%) cases. One case excreted for more than 6 months. None of the cases developed paralysis during the study period.Conclusions.aEuro integral Chronic polioviruses excretion remains a rare event even among individuals with PID. Nevertheless, because these individuals were not paralyzed they would have been missed by current surveillance; therefore, surveillance for polioviruses among PID should be established.