Gene regulation by the act of long non-coding RNA transcription.
Gene regulation by the act of long non-coding RNA transcription.
复制标题
DOI：
10.1186/1741-7007-11-59
复制
发表时间：
2013-05-30
期刊：
影响因子：
5.4
通讯作者：
Pauler FM
中科院分区：
文献类型：
--
作者：
Kornienko AE;Guenzl PM;Barlow DP;Pauler FM
Long-Non-Protein-Coding RNAs(Long Non-Protein-Coding RNAs，LncRNAs)被认为是小鼠和人类转录本中最大的转录类。两个重要的问题是，是否所有的lncRNA都具有功能，以及它们如何发挥功能。一些lncRNA已经被证明通过他们的产品发挥作用，但这并不是唯一可能的作用模式。在这篇综述中，我们着重于lncRNA转录过程在调节顺式调节蛋白编码基因活性中的作用，该过程独立于lncRNA产物。我们讨论了lncRNA转录导致基因沉默或激活的例子，并描述了确定lncRNA产物或其转录是否导致调控效应的策略。
Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in the mouse and human transcriptomes. Two important questions are whether all lncRNAs are functional and how they could exert a function. Several lncRNAs have been shown to function through their product, but this is not the only possible mode of action. In this review we focus on a role for the process of lncRNA transcription, independent of the lncRNA product, in regulating protein-coding-gene activity in cis. We discuss examples where lncRNA transcription leads to gene silencing or activation, and describe strategies to determine if the lncRNA product or its transcription causes the regulatory effect.