Cyclic structure with cellular precision in a vertebrate sensorimotor neural circuit.
Cyclic structure with cellular precision in a vertebrate sensorimotor neural circuit.
复制标题
脊椎动物感觉运动神经回路中具有细胞精度的循环结构。
DOI：
10.1016/j.cub.2023.05.010
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Seung,HSeb
中科院分区：
文献类型：
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作者：
Yang,Runzhe;Vishwanathan,Ashwin;Wu,Jingpeng;Kemnitz,Nico;Ih,Dodam;Turner,Nicholas;Lee,Kisuk;Tartavull,Ignacio;Silversmith,WilliamM;Jordan,ChrisS;David,Celia;Bland,Doug;Sterling,Amy;Goldman,MarkS;Aksay,EmreRF;Seung,HSeb
通过电子显微镜重建的神经元接线图1，2，3，4，5沿袭了跨物种比较的悠久传统，对神经系统的组织提出了新的问题。6，7C.优雅的连接体被概念化为一个感觉运动回路，大约是前馈的，8，9，10，11从感觉神经元开始，进入中间神经元，以运动神经元结束。一个3细胞基序的过度表达通常被称为“前馈环”，这为前馈性提供了进一步的证据。10，12在这里，我们与最近从斑马鱼幼虫脑中重建的另一个感觉运动线路图进行对比。13我们表明，3周期，另一个3细胞基序，在这个线路图的动眼运动模块中高度过度表达。这是通过电子显微镜重建的任何神经元配置图的第一次，无论是无脊椎动物12，14还是哺乳动物。15，16，17细胞的3周期与动眼神经模块的随机区块模型(SBM)18中的3周期神经元组“对齐”。然而，细胞周期表现出比群体周期更多的特异性--复发到相同的神经元是令人惊讶的常见。循环结构可能与依赖于循环连接性的动眼功能理论有关。循环结构与用于水平眼球运动的经典前庭-眼反射弧共存，19并且可能与眼球运动系统的时间整合的递归网络模型相关。
Neuronal wiring diagrams reconstructed by electron microscopy1,2,3,4,5pose new questions about the organization of nervous systems following the time-honored tradition of cross-species comparisons.6,7TheC. elegansconnectome has been conceptualized as a sensorimotor circuit that is approximately feedforward,8,9,10,11starting from sensory neurons proceeding to interneurons and ending with motor neurons. Overrepresentation of a 3-cell motif often known as the "feedforward loop" has provided further evidence for feedforwardness.10,12Here, we contrast with another sensorimotor wiring diagram that was recently reconstructed from a larval zebrafish brainstem.13We show that the 3-cycle, another 3-cell motif, is highly overrepresented in the oculomotor module of this wiring diagram. This is a first for any neuronal wiring diagram reconstructed by electron microscopy, whether invertebrate12,14or mammalian.15,16,17The 3-cycle of cells is "aligned" with a 3-cycle of neuronal groups in a stochastic block model (SBM)18of the oculomotor module. However, the cellular cycles exhibit more specificity than can be explained by the group cycles—recurrence to the same neuron is surprisingly common. Cyclic structure could be relevant for theories of oculomotor function that depend on recurrent connectivity. The cyclic structure coexists with the classic vestibulo-ocular reflex arc for horizontal eye movements,19and could be relevant for recurrent network models of temporal integration by the oculomotor system.20,21