Effects of intracerebroventricular injection of histamine on memory deficits induced by hippocampal lesions in rats.
Effects of intracerebroventricular injection of histamine on memory deficits induced by hippocampal lesions in rats.
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发表时间：
1997-05
影响因子：
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通讯作者：
C. Kamei;Z. Chen;S. Nakamura;Y. Sugimoto
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作者：
C. Kamei;Z. Chen;S. Nakamura;Y. Sugimoto
本实验研究了大鼠双侧海马区损毁对主动回避反应的影响，以及侧脑室注射(i.c.v.)注射组胺治疗海马区切除所致记忆障碍。在主动回避反应中，双侧背侧海马区受损导致学习习得迟缓。记忆保持能力也因海马区切除而受损。虽然在海马区损毁后，通过旷场测试测量的运动活动和养育行为增加，但学习障碍和探索行为的增加之间没有关系。I.C.V.注射组胺和ip。注射组氨酸可改善大鼠由海马区损毁所致的记忆障碍(不仅是学习习得，还包括记忆恢复)。海马切除后，海马区和下丘脑区的组胺含量下降，组胺(i.c.v.)可恢复这两个区域组胺含量的下降。和组氨酸(I.P.)注射。此外，在组胺注射后，回避反应潜伏期的缩短与海马区和下丘脑区组胺含量的增加之间存在密切关系。
The influence of bilateral hippocampal lesions on active avoidance response was studied in rats, as well as the effect of intracerebroventricular (i.c.v.) injection of histamine on memory deficits caused by hippocampectomy. Retardation of learning acquisition was produced by lesioning of the bilateral dorsal hippocampus in active avoidance response. Memory retention was also impaired by hippocampectomy. Although locomotor activity and rearing behavior measured by open-field test increased after hippocampal lesions, there was no relation between impairment of learning and increase in exploratory behavior. I.c.v. injection of histamine and i.p. injection of histidine resulted in an improvement of memory deficits (not only learning acquisition but also memory retrieval) induced by hippocampal lesions in rats. Histamine contents of the hippocampus and hypothalamus decreased after hippocampectomy, and a decrease in histamine contents of both areas was restored by histamine (i.c.v.) and histidine (i.p.) injection. In addition, a close relationship was found between decrease in response latency of avoidance response and an increase in histamine content of the hippocampus and hypothalamus after histamine injection.