Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: an analysis separating histogenetic types.
Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: an analysis separating histogenetic types.
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皮肤恶性黑色素瘤和总累积阳光照射指标：分离组织遗传学类型的分析。
DOI：
10.1093/jnci/73.1.75
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Bruce K. Armstrong
中科院分区：
文献类型：
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作者：
C. Holman;Bruce K. Armstrong
恶性黑色素瘤与过去阳光照射的半定量和问卷指标相关的证据来自西澳大利亚州511例患者和511例匹配对照受试者的病例对照研究。黑色素瘤与阳光照射有关，这一点得到了与光化性皮肤损伤的相关性的支持，光化性皮肤损伤由皮肤微地形、非黑色素性皮肤癌病史、移民到澳大利亚的居住时间以及受试者居住地的年平均日照时间进行分级。对组织发生亚型的单独分析显示，哈钦森的黑色素性雀斑黑色素瘤与日光照射指标的相关性最强。对于浅表扩散性黑色素瘤，观察到与到达时的年龄以及在澳大利亚的居住时间有特定的关系。10岁以前到达的移民似乎有与土生土长的澳大利亚人相似的风险，而15岁以后到达的移民的估计发病率约为土生土长的四分之一，年龄较晚到达没有额外的优势。10岁之前到达澳大利亚的对照受试者手臂上的痣数量增加，这表明早期生活中的阳光照射可能是痣产生的一个因素，因此，是以后发展为浅表扩散性黑色素瘤的决定因素。
Evidence associating malignant melanoma with semiquantitative and questionnaire indicators of past sunlight exposure is presented from a case-control study of 511 patients and 511 matched control subjects in Western Australia. That melanoma is related to sun exposure was supported by associations with actinic skin damage graded by cutaneous microtopography, history of nonmelanotic skin cancer, duration of residence of migrants to Australia, and mean annual hours of bright sunshine received at locations where the subjects had resided. Separate analyses of histogenetic subtypes revealed that Hutchinson's melanotic freckle melanoma had the strongest associations with indicators of sunlight exposure. For superficial spreading melanoma, a specific relationship was observed with age at arrival as against duration of residence in Australia. Migrants arriving before age 10 years appeared to have a risk similar to that of native-born Australians, whereas the estimated incidence in those arriving after age 15 years was around one-quarter of the native-born rate, with arrival at later ages giving no additional advantage. Control subjects arriving in Australia before age 10 years had an increased number of nevi on their arms, suggesting that sun exposure in early life may be a factor in nevus production and, therefore, a determinant of later potential to develop superficial spreading melanoma.