An analysis of normal variations in retinal nerve fiber layer thickness profiles measured with optical coherence tomography.
An analysis of normal variations in retinal nerve fiber layer thickness profiles measured with optical coherence tomography.
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DOI：
10.1097/ijg.0b013e3181650f8b
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发表时间：
2008-08
影响因子：
2
通讯作者：
Ritch R
中科院分区：
文献类型：
--
作者：
Ghadiali Q;Hood DC;Lee C;Manns J;Llinas A;Grover LK;Greenstein VC;Liebmann JM;Odel JG;Ritch R
目的：探讨光学相干断层扫描（OCT）测量视网膜神经纤维层（RNFL）厚度的正常变异。采用Zeiss Meditech公司的OCT 3型快速RNFL扫描仪对48名视力正常、屈光不正在±6.0D之间的个体（年龄56.4±9.5岁）进行了检查。他们的256点RNFL轮廓被导出用于分析。测量了RNFL分布的最大值的位置和峰值幅度。受试者间和两眼间的变化进行了评估的决定系数，R2。R2为1.0表明所有48个个体（或2只眼睛）的平均轮廓占单个眼睛轮廓的100%的变化。眼间比较的R2良好，平均值为0.91±0.07（右眼）和0.92±0.05（左眼）。个体特征与平均组特征比较的R2仅为0.61±0.29（右眼）和0.65±0.24（左眼），27%的R2值低于0.5。即使在通过其平均值标准化每个个体的轮廓之后，右（左）眼的R2仅为0.75±0.16（0.75±0.16）。右（左）眼的峰位置范围为上级峰超过91度（88度），下级峰超过64度（66度）。右（左）眼的峰值幅度范围分别跨越上级和下级峰值的1.7（1.8）和2.0（1.7）倍。有一个很大的变化幅度和形状的个人RNFL配置文件。然而，一个人的两只眼睛的RNFL轮廓非常相似。增加眼间比较OCT RNFL测试应该有助于识别一些假阳性。
To assess the normal variations in retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). Both eyes of 48 individuals (age 56.4±9.5 y) with normal vision and refractive errors between ±6.0D were tested with the fast RNFL scan protocol of the OCT3 (Zeiss Meditech). Their 256-point RNFL profiles were exported for analysis. The location and peak amplitude of the maxima of the RNFL profiles were measured. Intersubject and interocular variations were assessed with a coefficient of determination, R2. An R2 of 1.0 indicated that the average profile from all 48 individuals (or of the 2 eyes) accounted for 100% of the variation of an individual eye’s profile. The R2 for the interocular comparison was good, with averages of 0.91±0.07 (right eye) and 0.92±0.05 (left eye). The R2 for the comparison of the individual’s profile to the mean group profile was only 0.61±0.29 (right eye) and 0.65±0.24 (left eye), with 27% of the R2 values below 0.5. Even after normalizing each individual’s profile by its mean, R2 was only 0.75±0.16 (0.75±0.16) for the right (left) eye. The location of the peaks for the right (left) eye ranged over 91 degrees (88 degrees) for the superior peak and over 64 degrees (66 degrees) for the inferior peak. The range of peak amplitudes for the right (left) eye spanned a factor of 1.7 (1.8) and 2.0 (1.7) for the superior and inferior peaks, respectively. There was a wide variation in the amplitude and shape of the individual RNFL profiles. However, the RNFL profiles of the 2 eyes of an individual were extremely similar. Adding an interocular comparison with OCT RNFL tests should help identify some false positives.