Return to work after cell transplantation in patients with angiitis-induced critical limb ischaemia and factors related: a single-centre retrospective cohort study.
Return to work after cell transplantation in patients with angiitis-induced critical limb ischaemia and factors related: a single-centre retrospective cohort study.
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血管炎诱发的临界肢体缺血患者的细胞移植后恢复工作及其相关因素：一项单中心回顾性队列研究。
DOI：
10.1186/s13287-022-02807-1
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发表时间：
2022-04-01
影响因子：
7.5
通讯作者：
Dong Z
中科院分区：
文献类型：
--
作者：
Liu H;Liu Y;Pan T;Fang Y;Fang G;Jiang X;Chen B;Wei Z;Gu S;Liu P;Fu W;Dong Z
血管炎诱发的危重肢体缺血（AICLI）患者通常年轻且截肢率高，往往失去重返劳动力市场的能力。复工（RTW）不仅表明患者的身体健康，表明他们能够承担工作，也表明他们的心理健康。虽然细胞移植在保肢方面表现出令人满意的效果，但关于AICLI患者移植后RTW的研究报道较少。从2009年5月至2021年5月，回顾性纳入接受细胞移植并完成不少于12个月随访的AICLI患者。主要终点为RTW。回顾了患者的人口统计学特征和缺血肢体的特征，以分析RTW的独立危险因素。共纳入171例AICLI患者（男性170例），平均年龄41.9±9.6岁（范围：20-57岁）。12个月和24个月的RTW累积率分别为69.4%（95%可信区间[CI] 61.6-75.6%）和70.1% （95% CI 62.3-76.2%）。年龄< 40岁（比值比[OR] 2.659, 95% CI 1.138-6.719）和术前职业为脑力劳动者（比值比[OR] 8.930, 95% CI 2.665-42.847）被确定为RTW的独立保护因素。围手术期肢体感染合并溃疡或坏疽（or 0.250, 95% CI 0.075-0.779）被确定为独立危险因素。接受细胞移植的AICLI患者通常具有令人满意的中期RTW累积率。年龄< 40岁的AICLI患者术前职业为脑力劳动者，复工的可能性较大。围手术期预防肢体感染对RTW具有重要意义。
Angiitis-induced critical limb ischaemia (AICLI) patients, who are usually young and have a high amputation rate, always lose their ability to return to the labour force. Return to work (RTW) not only indicates patients’ physical health, showing that they could undertake the work, but also demonstrates their psychological well-being. While cell transplantation showed satisfactory efficacy in limb salvage, few studies of AICLI patients’ RTW after transplantation have been reported. From May 2009 to May 2021, AICLI patients who underwent cell transplantation and completed no less than 12 months of follow-up were retrospectively enrolled. The primary endpoint was RTW. Patient demographics and characteristics of the ischaemic limbs were reviewed to analyse independent risk factors for RTW. A total of 171 AICLI patients (170 males) were enrolled with a mean age of 41.9 ± 9.6 years (range: 20–57 years). The 12-month and 24-month RTW cumulative rates were 69.4% (95% confidence interval [CI] 61.6–75.6%) and 70.1% (95% CI 62.3–76.2%), respectively. Age < 40 years (odds ratio [OR] 2.659, 95% CI 1.138–6.719) and preoperative occupation as a mental worker (OR 8.930, 95% CI 2.665–42.847) were identified as independent protective factors for RTW. Perioperative limb infection with ulcer or gangrene (OR 0.250, 95% CI 0.075–0.779) was identified as an independent risk factor. AICLI patients who underwent cell transplantation usually had a satisfactory midterm RTW cumulative rate. AICLI patients < 40 years old with preoperative occupation as mental workers were more likely to return to work. Prevention of limb infection during the perioperative period is of great significance to RTW.
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