Functional CD32 molecules on human NK cells.
Functional CD32 molecules on human NK cells.
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DOI：
10.3109/10428199909145704
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发表时间：
1999-09
影响因子：
2.6
通讯作者：
P. A. Morel;Linda K. Ernst;Diana Metes
中科院分区：
文献类型：
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作者：
P. A. Morel;Linda K. Ernst;Diana Metes
人类 NK 细胞是大颗粒淋巴细胞，可利用穿孔素依赖性机制杀死肿瘤或病毒感染的靶标。 CD16 或 FcgammaRIII 是细胞表面分子之一，可在 IgG 的 Fc 部分与受体结合后触发杀伤机制：这种机制称为抗体依赖性细胞介导的细胞毒性 (ADCC)。我们最近发现，一些个体在其 NK 细胞、CD32 或 FcgammaRII 上表达额外的 FcgammaR。该受体现已在分子、生化和功能水平上得到表征。本综述概述了我们迄今为止关于这种新型受体特征的发现。这些发现表明，NK 细胞表面功能性 FcgammaRII 的存在可能在肿瘤免疫治疗和自身免疫性疾病中产生重要的临床后果。
Human NK cells are large granular lymphocytes that kill neoplastic or virally infected targets using perforin-dependent mechanisms. CD16 or FcgammaRIII is one of the cell surface molecules that can trigger the killing machinery following binding of the Fc portion of IgG to the receptor: a mechanism known as antibody dependent cell-mediated cytotoxicity (ADCC). We have recently shown that some individuals express an additional FcgammaR on their NK cells, CD32 or FcgammaRII. This receptor has now been characterized at the molecular, biochemical and functional level. The present review outlines our findings to date on the features of this novel receptor. These findings suggest that the presence of a functional FcgammaRII on the surface of NK cells could have important clinical consequences in both tumor immunotherapy and autoimmune disease.