Pathogenesis and pathophysiology of endometriosis.

Pathogenesis and pathophysiology of endometriosis.
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DOI:
10.1016/j.fertnstert.2012.06.029
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发表时间:
2012-09
影响因子:
6.7
通讯作者:
Giudice, Linda C.
Giudice, Linda C.
中科院分区:
医学2区
文献类型:
--
作者:
Burney, Richard O.;Giudice, Linda C.

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子宫内膜异位症最初是在三百多年前被描述的,经典的定义是子宫外部位的子宫内膜腺和间质。子宫内膜异位症是一种与盆腔疼痛和不孕症相关的炎症性雌激素依赖性疾病。这项工作回顾了疾病的过程,从起源的理论到疾病后遗症的分子基础。彻底了解子宫内膜异位症的组织病理学和病理生理学,对于开发新的诊断和治疗方法是至关重要的。
Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential toward the development of novel diagnostic and treatment approaches for this debilitating condition.
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