Hippocampal cellular and network activity in freely moving echolocating bats
Hippocampal cellular and network activity in freely moving echolocating bats
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DOI：
10.1038/nn1829
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发表时间：
2007-02-01
影响因子：
25
通讯作者：
Moss, Cynthia F.
中科院分区：
文献类型：
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作者：
Ulanovsky, Nachum;Moss, Cynthia F.
海马体对情景记忆和空间记忆至关重要。在自由运动的啮齿动物中，当动物通过神经元的“位置场”时，海马体锥体神经元表现出空间选择性放电，运动过程中θ波段振荡持续存在。在这里，我们报告了来自回声定位蝙蝠的第一个海马记录，这种哺乳动物在系统发育上与啮齿动物相距遥远，它显示了与啮齿动物非常相似的位置细胞。高频的“纹波”振荡也很像啮齿动物。然而，θ波振荡在两个重要方面与啮齿动物不同：(i)当蝙蝠在不移动的情况下探索环境时，通过回声定位使用远端传感，θ波振荡发生；(ii) θ波振荡不是连续的，而是在短时间内间歇性发生。间歇性的θ波表明，依赖于连续的θ波的海马功能模型可能不适用于蝙蝠。我们的数据支持这样的假设，即哺乳动物海马体中的θ波振荡与序列学习有关，因此，θ波功率应该随着感觉输入速率的增加而增加，这就解释了为什么θ波功率与啮齿动物的跑步速度和蝙蝠的回声定位率相关。
The hippocampus is crucial for episodic and spatial memory. In freely moving rodents, hippocampal pyramidal neurons show spatially selective firing when the animal passes through a neuron's 'place- field', and theta-band oscillation is continuously present during locomotion. Here we report the first hippocampal recordings from echolocating bats, mammals phylogenetically distant from rodents, which showed place cells very similar to those of rodents. High- frequency 'ripple' oscillations were also rodent- like. Theta oscillation, however, differed from rodents in two important ways: ( i) theta occurred when bats explored the environment without locomoting, using distal sensing through echolocation, and ( ii) theta was not continuous, but occurred in short intermittent bouts. The intermittence of theta suggests that models of hippocampal function that rely on continuous theta may not apply to bats. Our data support the hypothesis that theta oscillation in the mammalian hippocampus is involved in sequence learning and hence, theta power should increase with sensory- input rate-which explains why theta power correlates with running speed in rodents and with echolocation call rate in bats.