Parental socio-economic status and risk of first admission with schizophrenia - A Danish national register based study
Parental socio-economic status and risk of first admission with schizophrenia - A Danish national register based study
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DOI：
10.1007/s00127-004-0715-y
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发表时间：
2004-02-01
影响因子：
4.4
通讯作者：
Mortensen, PB
中科院分区：
文献类型：
--
作者：
Byrne, M;Agerbo, E;Mortensen, PB
背景我们研究了父母和个人社会经济地位的衡量标准与精神分裂症首次入院风险之间的关系，以确定病例中低社会经济地位是否是疾病过程的结果，还是家族危险因素。方法 以丹麦纵向登记为基础，开展了一项全国人群巢式病例对照研究。样本包括 1981 年至 1998 年间在丹麦精神病院收治的 7704 名首次入院的 ICD-8 或 ICD-10 精神分裂症患者，以及通过国家登记册确定的 192590 名个人时间、年龄和性别匹配的人群对照及其父母和兄弟姐妹。纳入入院前一年测量的社会经济指标以及病例、对照和家长的背景因素。结果 精神分裂症的风险与失业、低教育程度、单身、较低的财富状况、低收入和无子女有关。风险增加与精神疾病家族史、在城市地区出生、在丹麦境外出生以及有三个或以上兄弟姐妹有关。精神分裂症风险的增加与父母失业和父母收入较低有关，但与父母财富无关。精神分裂症的风险与父母的高等教育有关。结论 首次入院风险增加与病例的社会经济劣势相关。尽管我们发现父母失业、父母高等教育与精神分裂症风险之间存在一些关联，但几乎没有证据表明父母社会经济地位较低会增加精神分裂症风险。
Background We examined the relationships between measures of parental and personal socio-economic status and risk of first admission with schizophrenia in order to identify whether low socio-economic status in cases is a consequence of the illness process or is a familial risk factor. Methods A national population-based nested case-control study based on Danish longitudinal registers was conducted. The sample included 7704 first admissions with ICD-8 or ICD-10 schizophrenia admitted to a psychiatric facility in Denmark between 1981 and 1998 and 192 590 individually time-, age- and gender-matched population controls identified through national registers, and their parents and siblings. Socio-economic indicators measured in the year prior to admission and background factors for cases, controls, and parents were included. Results Risk of schizophrenia was associated with unemployment, low educational attainment, being single, lower wealth status, low income, and being childless. Increased risk was associated with a family history of psychiatric disorders, birth in urban areas, birth outside of Denmark, and having three of more siblings. Increased risk of schizophrenia was associated with parental unemployment and parental lower income, but was not associated with parental wealth. Risk for schizophrenia was associated with higher education in parents. Conclusions Increased risk of first admission was associated with socio-economic disadvantage in cases. Although we found some associations between parental unemployment and parental higher education and risk of schizophrenia, there was little evidence that low parental socio-economic status increases the risk of schizophrenia.