Efficient mapping of mendelian traits in dogs through genome-wide association
Efficient mapping of mendelian traits in dogs through genome-wide association
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DOI：
10.1038/ng.2007.10
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发表时间：
2007-11-01
期刊：
影响因子：
30.8
通讯作者：
Lindblad-Toh, Kerstin
中科院分区：
文献类型：
--
作者：
Karlsson, Elinor K.;Baranowska, Izabella;Lindblad-Toh, Kerstin
狗有数百种遗传疾病和有利的基因组结构，是绘制致病基因的理想选择。在这里，我们报告了一个基因分型阵列的开发，该阵列具有类似于27,000个snp，并表明仅用20只狗就可以实现狗品种孟德尔性状的全基因组关联图谱。具体来说，我们绘制了两个具有孟德尔遗传的性状：主要白色斑点(S)位点和罗得西亚背的毛脊。对于这两个性状，我们将基因座映射到的离散区域
With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with similar to 27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only similar to 20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting ( S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of