Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics
Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics
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DOI：
10.1016/0966-842x(94)90612-2
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发表时间：
1994-01-01
影响因子：
15.9
通讯作者：
Spratt, Brian G.
中科院分区：
文献类型：
--
作者：
Dowson, Christopher G.;Coffey, Tracey J.;Spratt, Brian G.
在一些自然可转化的细菌病原体中，对β-内酰胺抗生素的耐药性是由种间重组事件引起的，这些重组事件产生了对抗生素亲和力降低的杂合青霉素结合蛋白。这种类型的耐药性在肺炎球菌中特别令人关注，在世界范围内这种耐药性正在增加。
Resistance to β-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.