Classical pathway complement activity in schizophrenia
Classical pathway complement activity in schizophrenia
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DOI：
10.1016/j.neulet.2004.10.024
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发表时间：
2005-02-01
影响因子：
2.5
通讯作者：
Sim, RB
中科院分区：
文献类型：
--
作者：
Hakobyan, S;Boyajyan, A;Sim, RB
有相当多的证据表明补体在精神分裂症的发病机制中起作用，但与精神分裂症患者经典途径补体活性相关的数据相互矛盾。本文测定了有阳性家族史的精神分裂症患者和健康人血清中补体的总溶血活性和补体C_1、C_2、C_3和C_4的活性。与健康人相比，精神分裂症患者血清中补体C1、C3和C4成分的溶血活性的平均值显著较高，补体C2成分的溶血活性的平均值显著较低。但精神分裂症患者与健康人补体总溶血活性的平均值无显著性差异。服药患者的C3溶血活性比未服药患者高2.17倍。在每一组中，吸烟者和不吸烟者之间或男性和女性之间没有显着差异。本研究的结果表明，精神分裂症的发病机制与补体经典途径成分的活性改变有关。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
There is considerable evidence to Suggest a role for complement in the pathogenesis of schizophrenia, but the data related to the classical pathway complement activity in patients with schizophrenia are conflicting. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3 and C4, were determined in the blood serum of schizophrenic patients with positive family history of the disease and healthy subjects. In comparison to the healthy subjects, the mean values of the hemolytic activities of the C1, C3 and C4 complement components in the serum of the schizophrenic patients were significantly higher, and the mean value of the hemolytic activity of the C2 complement component was significantly lower. However, no significant difference was found between the mean values of the total hemolytic activity of complement in schizophrenic patients and healthy subjects. The C3 hemolytic activity was 2.17 times higher in medicated patients than in drug-free patients. Within each group examined no significant difference was found between smokers and non-smokers or between males and females. The results of this study suggest that the pathogenesis of schizophrenia is associated with alterations in activities of complement classical pathway components. (C) 2004 Elsevier Ireland Ltd. All rights reserved.