Second primary cancer after index head and neck squamous cell carcinoma in Northern China
Second primary cancer after index head and neck squamous cell carcinoma in Northern China
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中国北方继头颈鳞状细胞癌之后的第二原发癌
DOI：
10.1016/j.oooo.2016.08.013
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发表时间：
2017-01-01
影响因子：
2.9
通讯作者：
Han, Zhengxue
中科院分区：
文献类型：
--
作者：
Feng, Zhien;Xu, Qiao Shi;Han, Zhengxue
客观的。旨在评估华北人群中发生第二原发性恶性肿瘤（SPM）的头颈鳞状细胞癌（HNSCC）患者的临床病理特征、预后因素和治疗。方法。这是一项回顾性研究，纳入了 1999 年 6 月至 2011 年 4 月期间的 1818 名符合条件的患者。结果。共有 188 名 HNSCC 患者出现 SPM。多发性口腔发育不良病变 (MODL) (P < .001) 是 SPM 发生的危险因素之一。然而，MODL 与许多轻度病理特征密切相关，例如早期 T 期 (P < .001)、早期 N 期 (P = .036)、良好的病理分化 (P < .001) 和轻度生长模式 (P < .001)。有趣的是，多变量生存分析表明，如果 SPM 患者具有 MODL 的特征，则其预后更好 (P = .020)。结论。 MODLs 是导致中国北方患者 HNSCC 后发生口腔 SPM 的关键危险因素。然而，具有MODLs特征的SPM患者预后较好。
Objective. To evaluate the clinicopathologic features, prognostic factors, and management of patients in the North Chinese population with head and neck squamous cell carcinoma (HNSCC) who developed a second primary malignancy (SPM).Methods. This was a retrospective study including 1818 eligible patients between June 1999 and April 2011.Results. A total of 188 HNSCC patients developed SPM. Multiple oral dysplastic lesions (MODLs) (P < .001) were among the risk factors for occurrence of SPM. However, MODLs were closely associated with many mild pathologic features, such as early T stage (P < .001), early N stage (P = .036), good pathologic differentiation (P < .001), and mild growth pattern (P < .001). Interestingly, multivariate survival analysis showed that SPM patients had a better prognosis if they had the characteristics of MODLs (P = .020).Conclusions. MODLs were a crucial risk factor leading to the occurrence of oral SPM after an index HNSCC in patients in Northern China. However, SPM patients with the characteristics of MODLs had a better prognosis.