Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease
Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease
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DOI：
10.1016/j.brainresbull.2006.08.015
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发表时间：
2006-12-11
影响因子：
3.8
通讯作者：
Foffani, G.
中科院分区：
文献类型：
--
作者：
Priori, A.;Ardolino, G.;Foffani, G.
这项工作是一系列论文中的第二篇，在这些论文中，我们使用植入帕金森病患者丘脑底核（DBS）的DBS电极的术后局部场电位（LFP）记录研究了脑深部电刺激（DBS）临床疗效的神经生理学基础。我们发现，帕金森病患者脑深部电刺激后LFP记录中的低频（1-1.5 Hz）振荡显著增加（对数功率变化= 0.93 +/- 0.62; Wilcoxon：p = 0.0002，n = 13），关闭脑深部电刺激后缓慢衰减至基线水平。DBS诱导的低频LFP振荡增加具有高度可重复性，并且仅在DBS输送足够长的时间以诱导临床改善后才出现。低频LFP振荡的这种增加可以反映刺激诱导的网络活动的调制，或者可以代表脑电极界面处的电化学性质的变化。(c)2006爱思唯尔公司All rights reserved.
This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change = 0.93 +/- 0.62; Wilcoxon: p = 0.0002, n = 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface. (c) 2006 Elsevier Inc. All rights reserved.