A network meta-analysis of association between cardiometabolic risk factors and COVID-19 outcome severity.
A network meta-analysis of association between cardiometabolic risk factors and COVID-19 outcome severity.
复制标题
DOI：
10.1111/1753-0407.13445
复制
发表时间：
2023-11
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
心脏代谢合并症与COVID-19严重程度和死亡率的风险较高相关，但需要进行更多的研究以确定哪种合并症更有害。对Embase、Emcare和MEDLINE进行了系统性检索，以获得前瞻性和回顾性研究，这些研究评估了COVID-19诊断患者中心脏代谢风险因素与COVID-19住院结局、严重程度和死亡率的相关性。从首次发表到2021年5月19日进行了文献检索。通过纽卡斯尔-渥太华量表评估研究质量。从文献检索中，301项研究表明，所有纳入的心脏代谢风险因素均与COVID-19住院、严重程度和死亡率的较高风险相关，但超重与死亡率风险降低相关（相对风险[RR] 0.88; 95%CI，0.80 - 0.98）。糖尿病患者（RR 1.46; 95%CI，1.45 - 1.47）最有可能住院;心力衰竭患者发生严重COVID-19结局的风险最高（RR 1.89; 95%CI，1.71 - 2.09）;而卒中患者最易发生总死亡率（RR 1.99; 95%CI，1.90 - 2.08）。在网络荟萃分析中，与其他心脏代谢风险因素相比，脑血管疾病对COVID-19结局的影响最大（RR 1.69; 95% CI，1.65 - 1.73）。对于不同的危险因素组合，心血管疾病和糖尿病的组合（RR 6.98; 95%CI，5.28 - 9.22）比其他更有害。考虑到心脏代谢合并症的高患病率和所有严重结局的风险，在COVID-19的疫苗接种和治疗开发中，应优先考虑心脏代谢合并症患者。在301项研究中，糖尿病是研究最多的心脏代谢危险因素。在网络荟萃分析中，与其他心脏代谢风险因素相比，脑血管疾病对COVID-19结局的影响最大（相对风险[RR] 1.69; 95% CI，1.65 - 1.73）。对于不同的危险因素组合，心血管疾病和糖尿病合并（RR 6.98; 95%CI，5.28 - 9.22）比其他更有害。 亮点
Cardiometabolic comorbidities have been associated with a higher risk of COVID‐19 severity and mortality, but more investigations are needed to determine which comorbidity is more detrimental. Embase, Emcare, and MEDLINE were searched systematically for prospective and retrospective studies assessing the associations of cardiometabolic risk factors and COVID‐19 outcomes of hospitalization, severity, and mortality among COVID‐19‐diagnosed patients. Literature search was performed from first publication to May 19, 2021. Study quality was assessed by the Newcastle‐Ottawa Scale. From the literature search, 301 studies suggested that all included cardiometabolic risk factors were associated with a higher risk of COVID‐19 hospitalization, severity, and mortality, except that overweight was associated with a decreased risk of mortality (relative risk [RR] 0.88; 95% CI, 0.80–0.98). Patients with diabetes (RR 1.46; 95% CI, 1.45–1.47) were most likely to be hospitalized; patients with heart failure had the highest risk for severe COVID‐19 outcomes (RR 1.89; 95% CI, 1.71–2.09); while patients with stroke were most susceptible to overall mortality (RR 1.99; 95% CI, 1.90–2.08). In the network meta‐analysis, cerebrovascular disease had the highest impact (RR 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors. For different combinations of risk factors, cardiovascular disease and diabetes combined (RR 6.98; 95% CI, 5.28–9.22) was more detrimental than others. Considering the high prevalence of cardiometabolic comorbidities and risk of all severe outcomes, patients with cardiometabolic comorbidities should be prioritized in vaccination and treatment development of COVID‐19. Among 301 studies, diabetes mellitus was the most studied cardiometabolic risk factor. In the network meta‐analysis, cerebrovascular disease had the highest impact (relative risk [RR] 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors. For different combinations of risk factors, cardiovascular disease and diabetes mellitus combined (RR 6.98; 95% CI, 5.28–9.22) was more detrimental than others. Highlights
登录
查看更多内容
影响因子：
13.8
作者：
Ioannou GN;Green P;Fan VS;Dominitz JA;O'Hare AM;Backus LI;Locke E;Eastment MC;Osborne TF;Ioannou NG;Berry K
通讯作者：
Berry K
肾素 - 血管紧张素 - 醛固酮系统阻滞剂和COVID-19结果中的区域特异性变化：来自系统的综述和荟萃分析的结果。
影响因子：
4.4
作者：
Kaur U;Chakrabarti SS;Patel TK
通讯作者：
Patel TK
影响因子：
24.5
作者：
Dufour, Jean-Francois;Marjot, Thomas;Tilg, Herbert
通讯作者：
Tilg, Herbert
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing
影响因子：
9.3
作者：
Awortwe C;Cascorbi I
通讯作者：
Cascorbi I