Transport stress-induced cerebrum oxidative stress is not mitigated by activating the Nrf2 antioxidant defense response in newly hatched chicks
Transport stress-induced cerebrum oxidative stress is not mitigated by activating the Nrf2 antioxidant defense response in newly hatched chicks
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DOI：
10.2527/jas.2017.1559
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发表时间：
2017-07-01
影响因子：
3.3
通讯作者：
Li, J. -L.
中科院分区：
文献类型：
--
作者：
Ge, J.;Li, H.;Li, J. -L.
新孵化的雏鸡从孵化场运输到农场是不可避免的，特别是对于父母代鸡和祖代父母代鸡而言。然而，人们对运输压力对刚孵出的雏鸡可能产生的影响知之甚少。本研究的目的是通过激活核因子红细胞 2 相关因子 2 (Nrf2) 诱导的抗氧化防御来确定对运输应激的适应性反应。将120只初孵雏鸡分为3组（对照组、运输组和模拟运输组），分别进行2、4和8 h的真实或模拟运输。运输应激可能会通过增加脂质过氧化和自由基的产生以及降低抗氧化酶的活性和谷胱甘肽与氧化型谷胱甘肽的比率，从而在新孵出的雏鸡的大脑中引起氧化应激。运输应激激活 Nrf2 信号通路并触发抗氧化参数的转录。然而，在新孵化的雏鸡中，激活 Nrf2 抗氧化防御反应并不能减轻运输应激诱导的大脑氧化应激。
Transportation of newly hatched chicks from the hatchery to the farm is inevitable, especially for parent stock and grandsire parent stock chicks. However, the possible effects of transport stress in the newly hatched chicks are poorly understood. The aim of this study was to determine the adaptive responses to transport stress by activing the nuclear factor-erythroid 2-related factor 2 (Nrf2)-induced antioxidant defense. One hundred twenty newly hatched chicks were divided into 3 groups (control group, transport group, and simulation transport group) for 2, 4, and 8 h of real or simulated transportation. Transport stress could cause oxidative stress in the cerebrum of newly hatched chicks by increasing lipid peroxidation and production of free radicals and decreasing the activities of antioxidant enzymes and the glutathione: oxidized glutathione ratio. Transport stress activated the Nrf2 signaling pathway and triggered the transcription of antioxidant parameters. However, transport stress-induced cerebrum oxidative stress was not mitigated by activating the Nrf2 antioxidant defense response in newly hatched chicks.