Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment.
Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment.
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DOI：
10.1158/2159-8290.cd-19-1353
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发表时间：
2020-05
期刊：
影响因子：
28.2
通讯作者：
Sherman MH
中科院分区：
文献类型：
--
作者：
Helms E;Onate MK;Sherman MH
胰腺导管腺癌（PDAC）患者的预后不良促使人们对疾病生物学的理解，以促进更好的治疗方法的发展。PDAC通常以显著致密的基质反应为特征，其特征在于由显著的癌症相关成纤维细胞群体建立。基因工程小鼠模型和日益复杂的细胞培养技术已经证明成纤维细胞在PDAC进展和治疗反应中的重要作用，但这些作用是复杂的，有强有力的证据表明肿瘤支持和肿瘤抑制或稳态功能。在这里，我们回顾了最近的文献，提高了我们的理解异质性成纤维细胞的命运和功能在这种疾病中，包括不同的成纤维细胞群体的存在，并强调未来的研究的重要途径。
The poor prognosis for pancreatic ductal adenocarcinoma (PDAC) patients impels an improved understanding of disease biology, to facilitate the development of better therapies. PDAC typically features a remarkably dense stromal reaction, featuring and established by a prominent population of cancer-associated fibroblasts. Genetically engineered mouse models and increasingly sophisticated cell culture techniques have demonstrated important roles for fibroblasts in PDAC progression and therapy response, but these roles are complex, with strong evidence for both tumor-supportive and tumor-suppressive or homeostatic functions. Here we review the recent literature which has improved our understanding of heterogeneity in fibroblast fate and function in this disease including the existence of distinct fibroblast populations, and highlight important avenues for future study.