Muscarinic Receptors
Muscarinic Receptors
复制标题
毒蕈碱受体
DOI：
10.1007/978-3-642-23274-9
复制
发表时间：
2012
期刊：
影响因子：
3.5
通讯作者：
N. Nathanson
中科院分区：
文献类型：
--
作者：
A. Fryer;A. Christopoulos;N. Nathanson
毒蕈碱受体的生理作用非常复杂，尽管尚未完全了解，但在过去十年中已变得更加清晰。最近的药理学证据与新的化合物，以及转基因小鼠的数据表明，所有五个亚型在神经系统中的功能，以及介导的非神经元，乙酰胆碱的激素作用。许多新的激动剂，变构调节剂和拮抗剂，现在已经确定了真正的亚型特异性在体外和体内。这些化合物为选择性亚型调节以及新一代基于毒蕈碱受体的治疗剂提供了额外的药理学机会。
The physiological role of muscarinic receptors is highly complex and, although not completely understood, has become clearer over the last decade. Recent pharmacological evidence with novel compounds, together with data from transgenic mice, suggests that all five subtypes have defined functions in the nervous system as well as mediating the non neuronal, hormonal actions of acetylcholine. Numerous novel agonists, allosteric regulators, and antagonists have now been identified with authentic subtype specificity in vitro and in vivo. These compounds provide additional pharmacological opportunities for selective subtype modulation as well as a new generation of muscarinic receptor-based therapeutics.