DIETARY IMMUNOREGULATION OF TRANSFUSION‐INDUCED IMMUNOSUPPRESSION
DIETARY IMMUNOREGULATION OF TRANSFUSION‐INDUCED IMMUNOSUPPRESSION
复制标题
输血的饮食免疫调节——引起的免疫抑制
作者：
R. Perez;R. Munda;J. Alexander
在大鼠心脏移植模型中，进行脂肪酸膳食补充以检查膳食操作的类型和时间是否会对输血诱导的免疫抑制产生影响。亚油酸（LA）、油酸（OA）和鱼油（FO）对花生四烯酸（AA）代谢的影响不同，因此使用了它们。与喂水对照相比，移植前抑制AA代谢（OA）缩短了移植物存活时间。移植后LA（AA前体）显着延长移植物存活。移植前和移植后补充LA和OA分别导致移植物存活时间延长和缩短。这些结果表明，输血诱导的免疫抑制部分介导的AA代谢物，这是必要的移植前诱导和移植后维持抑制状态。输血诱导的免疫抑制的饮食免疫调节是可能的。饮食干预的时机和脂质补充剂的类型在调节免疫应答方面很重要。
Dietary supplementation with fatty acids was carried out to examine whether the type and timing of dietary manipulation would have an effect on transfusion-induced immunosuppression in a rat cardiac transplant model. Linoleic acid (LA), oleic acid (OA), and fish oil (FO) were used because of their different effects on arachidonic acid (AA) metabolism. Pretransplant inhibition of AA metabolism (OA) shortened graft survival when compared with water-fed controls. Posttransplant LA (AA precursor) significantly prolonged graft survival. Pre-and posttransplant supplementation of LA and OA resulted in even more prolongation and shortening of graft survival, respectively. These findings suggest that transfusion-induced immunosuppression is partially mediated by AA metabolites, which are necessary for the pretransplant induction and posttransplant maintenance of the suppressed state. Dietary immunoregulation of transfusion induced immunosuppression is possible. The timing of dietary intervention and type of lipid supplementation is important in regulation of the immune response.