'Silent' flagellin drives immunotolerance to commensal bacteria.
'Silent' flagellin drives immunotolerance to commensal bacteria.
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“沉默”鞭毛蛋白驱动对共生细菌的免疫耐受。
DOI：
10.1016/j.it.2023.01.010
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发表时间：
2023
影响因子：
16.8
通讯作者：
Zhou,Liang
中科院分区：
文献类型：
--
作者：
Xiong,Lifeng;Zhou,Liang
区分细菌和致病菌以产生适当的反应（耐受性与免疫原性）是人类免疫系统必须做出的维持体内平衡的关键决定。最近，Clasen及其同事报道了细菌鞭毛蛋白和宿主Toll样受体5（TLR5）之间独特的变构相互作用，这可能揭示了这些差异。
Distinguishing between commensal and pathogenic bacteria to generate appropriate responses (tolerance vs. immunogenicity) is a key decision that the human immune system must make to maintain homeostasis. Recently, Clasen and colleagues reported a distinct allosteric interaction between bacterial flagellin and host Toll-like receptor 5 (TLR5), which may shed light on these differences.