Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex.
Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex.
复制标题
NMDA受体和L型钙通道对梨状皮层长期抑郁的年龄依赖性贡献。
DOI：
10.3390/ijms222413551
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发表时间：
2021-12-17
影响因子：
5.6
通讯作者：
Yuan Q
中科院分区：
文献类型：
--
作者：
Rajani V;Maziar A;Man KNM;Hell JW;Yuan Q
In the hippocampus, the contributions of N-methyl-D-aspartate receivers (NMDARs) and L-type calcium channels (LTCCs) to neuronal transmission and synaptic plasticity change with aging, underlying calcium dysregulation and cognitive dysfunction. However, the relative contributions of NMDARs and LTCCs in other learning encoding structures during aging are not known. The piriform cortex (PC) plays a significant role in odor associative memories, and像海马一样，在这里表现出长期的突触可塑性，我们研究了在三个sprague dawley老鼠中的长期抑郁症（LTD）中NMDAR和LTCC的表达和贡献。肤色免疫组织化学和共焦成像，尽管LTD表达的量没有差异，但我们观察到了老年大鼠的LTCC介导LTCC的转变。 ed嗅觉功能和衰老的学习。
In the hippocampus, the contributions of N-methyl-D-aspartate receptors (NMDARs) and L-type calcium channels (LTCCs) to neuronal transmission and synaptic plasticity change with aging, underlying calcium dysregulation and cognitive dysfunction. However, the relative contributions of NMDARs and LTCCs in other learning encoding structures during aging are not known. The piriform cortex (PC) plays a significant role in odor associative memories, and like the hippocampus, exhibits forms of long-term synaptic plasticity. Here, we investigated the expression and contribution of NMDARs and LTCCs in long-term depression (LTD) of the PC associational fiber pathway in three cohorts of Sprague Dawley rats: neonatal (1–2 weeks), young adult (2–3 months) and aged (20–25 months). Using a combination of slice electrophysiology, Western blotting, fluorescent immunohistochemistry and confocal imaging, we observed a shift from an NMDAR to LTCC mediation of LTD in aged rats, despite no difference in the amount of LTD expression. These changes in plasticity are related to age-dependent differential receptor expression in the PC. LTCC Cav1.2 expression relative to postsynaptic density protein 95 is increased in the associational pathway of the aged PC layer Ib. Enhanced LTCC contribution in synaptic depression in the PC may contribute to altered olfactory function and learning with aging.
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影响因子：
5.7
作者：
Blazing RM;Franks KM
通讯作者：
Franks KM
影响因子：
3.5
作者：
Hu Z;Liang MC;Soong TW
通讯作者：
Soong TW
DOI：
10.1073/pnas.1008200107
发表时间：
2010-09-21
影响因子：
11.1
作者：
Ge, Yuan;Dong, Zhifang;Wang, Yu Tian
通讯作者：
Wang, Yu Tian
DOI：
10.1016/0005-2736(71)90117-9
发表时间：
1971-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
COTMAN, CW;MATTHEWS, DA
通讯作者：
MATTHEWS, DA
影响因子：
4.8
作者：
Gaburjakova, M;Gaburjakova, J;Marks, AR
通讯作者：
Marks, AR