Individual differences in rats' reactivity to novelty and the unconditioned and conditioned locomotor effects of methamphetamine
Individual differences in rats' reactivity to novelty and the unconditioned and conditioned locomotor effects of methamphetamine
复制标题
DOI：
10.1016/j.pbb.2004.06.002
复制
发表时间：
2004-09-01
影响因子：
3.6
通讯作者：
Peterson, JL
中科院分区：
文献类型：
--
作者：
Bevins, RA;Peterson, JL
大鼠对不可避免的新奇事物的反应可以预测许多刺激物随后的心理效应。尚未对甲基苯丙胺的这种关系进行检查。实验1评估了甲基苯丙胺（0.0625-1.0 mg/kg）的运动效应。平均而言，甲基苯丙胺（0.25，0.5和1毫克/公斤）的急性给药对活动有刺激作用;运动致敏后，重复给药0.5和1毫克/公斤。在随后的无药物测试中，大鼠的运动室与0.25，0.5或1毫克/公斤的甲基苯丙胺在八个不同的场合配对比对照组条件性多动更活跃。实验2使用0.5毫克/公斤的剂量，以检查是否强迫新奇接触（新奇诱导的活动）或自由选择新奇（新的环境或物体相互作用的方法）是预测甲基苯丙胺的精神影响。只有对不可避免的新奇的反应与甲基苯丙胺诱导的活性系统相关。对新奇事物反应更强烈的大鼠[高反应者（HR）]对急性和慢性甲基苯丙胺挑战更活跃。此外，这些HR比低反应者（LR）表现出更多的条件性多动。虽然急性甲基苯丙胺并没有刺激LR的效果，只有LR显示运动敏化慢性甲基苯丙胺后。这项研究扩展了预测变量的反应，不可避免的新奇甲基苯丙胺的条件和非条件运动的影响。(C)2004年爱思唯尔公司All rights reserved.
Rat's reactivity to inescapable novelty can predict the subsequent psychomotor effects of many stimulants. This relation has not been examined for methamphetamine. Experiment 1 assessed the locomotor effects of methamphetamine (0.0625-1.0 mg/kg). On average, acute administration of methamphetamine (0.25, 0.5, and 1 mg/kg) had a stimulant effect on activity; locomotor sensitization was seen after repeated administration of 0.5 and 1 mg/kg. In a subsequent drug-free test, rats that had the locomotor chamber paired with 0.25, 0.5, or 1 mg/kg methamphetamine on eight separate occasions were more active than controls-conditioned hyperactivity. Experiment 2 used the 0.5-mg/kg dose to examine whether forced novelty exposure (novelty-induced activity) or free-choice novelty (approach to novel environment or object interaction) was predictive of methamphetamine's psychomotor effects. Only reactivity to inescapable novelty was systematically correlated with methamphetamine-induced activity. Rats more reactive to novelty [high responders (HR)] were more active to the acute and chronic methamphetamine challenge. Furthermore, these HR showed more conditioned hyperactivity than low responders (LR). Although acute methamphetamine did not have a stimulant effect in LR, only the LR displayed locomotor sensitization after chronic methamphetamine. This research extends the predictive variable of reactivity to inescapable novelty to methamphetamine's conditioned and unconditioned locomotor effects. (C) 2004 Elsevier Inc. All rights reserved.