The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone.
The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone.
复制标题
DOI：
10.1126/science.6234658
复制
发表时间：
1984-07
期刊：
影响因子：
56.9
通讯作者：
C. Seidman;A. Duby;E. Choi;R. Graham;E. Haber;C. Homcy;J. Smith;J. Seidman
中科院分区：
文献类型：
--
作者：
C. Seidman;A. Duby;E. Choi;R. Graham;E. Haber;C. Homcy;J. Smith;J. Seidman
通过对大鼠前心钠素原（preproANF）互补DNA克隆的核苷酸序列分析，确定了其结构。PreproANF由疏水前导片段（20个氨基酸）、含有一个糖基化位点的前体（106个氨基酸）和ANF（24个氨基酸）组成。心房利钠因子位于前体分子的羧基末端。人类、小鼠和大鼠基因组各自含有高度保守的单个ANF基因。
The structure of rat preproatrial natriuretic factor ( preproANF ) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.