Immunotherapy of murine leukemia. V. Protection against Friend leukemia virus-induced immune complex glomerulonephritis by passive serum therapy.
Immunotherapy of murine leukemia. V. Protection against Friend leukemia virus-induced immune complex glomerulonephritis by passive serum therapy.
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DOI：
10.1093/jnci/67.3.703
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发表时间：
1981-09
期刊：
影响因子：
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通讯作者：
F. Sanfilippo;E. Genovesi;J. Collins
中科院分区：
文献类型：
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作者：
F. Sanfilippo;E. Genovesi;J. Collins
本文比较了Friend鼠白血病病毒（F-MuLV）感染DBA/2小鼠和给予黑猩猩抗F-MuLV抗血清（CaF-MuLV）保护的小鼠免疫复合物肾炎的发展。从病毒血症（感染）正常黑猩猩血清治疗的动物肾小球的形态学分析显示，在病毒接种后2周内出现显著的肾脏疾病，肾小球免疫复合物沉积和C型病毒颗粒，通过电子显微镜观察。还通过免疫荧光检测了F-MuLV包膜和核心抗原（分别为gp 71和p30）的定位，以及鼠IgG和C3。然而，年龄匹配的DBA/2小鼠单独用CaF-MuLV抗血清治疗或F-MuLV接种后，没有表现出全身性疾病的证据，既没有F-MuLV抗原的定位，也没有可检测到的病毒颗粒。这些数据表明，除了红白血病，F-MuLV感染导致严重的免疫复合物肾小球肾炎，被动免疫治疗可以保护易感小鼠免受病毒发病机制的两个方面。
The development of immune complex glomerulonephritis in DBA/2 mice infected with Friend murine leukemia virus (F-MuLV) was compared with that in mice protected against virus-induced disease by administration of chimpanzee anti-F-MuLV antiserum (CaF-MuLV). Morphologic analysis of glomeruli from viremic (infected) normal chimpanzee serum-treated animals revealed significant renal disease within 2 weeks following virus inoculation, with glomerular immune complex deposits and C-type viral particles seen by electron microscopy. Localization of F-MuLV envelope and core antigens (gp71 and p30, respectively) was also detected by immunofluorescence, as was murine IgG and C3. However, age-matched DBA/2 mice treated with CaF-MuLV antiserum alone or following F-MuLV inoculation showed no evidence of systemic disease and neither localization of F-MuLV antigens nor detectable virus particles. These data indicate that in addition to erythroleukemia, F-MuLV infection results in severe immune complex glomerulonephritis and that passive immunotherapy can protect susceptible mice from both aspects of viral pathogenesis.