Roles of BMP signaling pathway in lip and palate development.
Roles of BMP signaling pathway in lip and palate development.
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DOI：
10.1159/000337617
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Chai Y
中科院分区：
文献类型：
--
作者：
Parada C;Chai Y
唇裂伴或不伴腭裂（CLP）和单纯腭裂（CP）是影响口面结构的严重破坏。口面裂患者需要复杂的跨学科护理，其中包括护理、整形外科、颌面外科、耳鼻喉科、言语治疗、听力学、心理和遗传咨询、正畸学和牙科治疗等。总的来说，唇腭裂的治疗给家庭和社会带来了巨大的经济负担。因此，预防是最终的目标，这将有助于对这种情况的病因学的全面了解。在这里，我们回顾了目前的概念，关于遗传和环境因素的口面裂，并强调BMP信号通路的组成部分在唇和腭的正常和异常的发展中的作用。
Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are severe disruptions affecting orofacial structures. Patients with orofacial clefts require complex interdisciplinary care, which includes nursing, plastic surgery, maxillofacial surgery, otolaryngology, speech therapy, audiology, psychological and genetic counseling, orthodontics and dental treatment, among others. Overall, treatment of clefts of the lip and palate entails a significant economic burden for families and society. Therefore, prevention is the ultimate objective and this will be facilitated by a complete understanding of the etiology of this condition. Here we review the current concepts regarding the genetic and environmental factors contributing to orofacial clefts and emphasize on the roles of BMP signaling pathway components in the normal and aberrant development of the lip and palate.