Para-hydrogen perspectives in hyperpolarized NMR
Para-hydrogen perspectives in hyperpolarized NMR
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DOI：
10.1016/j.jmr.2013.07.010
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发表时间：
2013-10-01
影响因子：
2.2
通讯作者：
Appelt, Stephan
中科院分区：
文献类型：
--
作者：
Gloeggler, Stefan;Colell, Johannes;Appelt, Stephan
核磁共振实验中的第一个对氢诱导极化 (PHIP) 是在 20 世纪 80 年代研究氢化反应时偶然观察到的（Seldler 等人，1983；Bowers 和 Weitekamp，1986、1987；Eisenschmid 等人，1987）[1-4]。值得注意的是，对仲氢作为超极化剂的适用性的理论研究正在 20 世纪 80 年代进行，从而迅速为 PHIP 效应提供了理论基础（Bowers 和 Weitekamp，1986）[2]。通过与仲氢的非氢化相互作用实现信号放大的发现最近引起了人们对利用 PHIP 效应的兴趣，因为它能够在不改变结构的情况下研究化合物，同时保留超极化化合物光谱的优点 [5]。在本文中，我们将更加强调该方法的未来应用，同时仅简要讨论已经做出的努力。迄今为止对现象的理解和方法的发展。 (c) 2013 Elsevier Inc. 保留所有权利。
The first instance of para-hydrogen induced polarization (PHIP) in an NMR experiment was serendipitously observed in the 1980s while investigating a hydrogenation reaction (Seldler et al., 1983; Bowers and Weitekamp, 1986, 1987; Eisenschmid et al., 1987) [1-4]. Remarkably a theoretical investigation of the applicability of para-hydrogen as a hyperpolarization agent was being performed in the 1980's thereby quickly providing a theoretical basis for the PHIP-effect (Bowers and Weitekamp, 1986) [2]. The discovery of signal amplification by a non-hydrogenating interaction with para-hydrogen has recently extended the interest to exploit the PHIP effect, as it enables investigation of compounds without structural alteration while retaining the advantages of spectroscopy with hyperpolarized compounds [5]. In this article we will place more emphasis of the future applications of the method while only briefly discussing the efforts that have been made. in the understanding of the phenomenon and the development of the method so far. (c) 2013 Elsevier Inc. All rights reserved.