Expression of Notch1 and Numb in small cell lung cancer.
Expression of Notch1 and Numb in small cell lung cancer.
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DOI：
10.18632/oncotarget.14411
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发表时间：
2017-02-07
期刊：
影响因子：
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通讯作者：
Nishimura M
中科院分区：
文献类型：
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作者：
Kikuchi H;Sakakibara-Konishi J;Furuta M;Yokouchi H;Nishihara H;Yamazaki S;Uramoto H;Tanaka F;Harada M;Akie K;Sugaya F;Fujita Y;Takamura K;Kojima T;Harada T;Higuchi M;Honjo O;Minami Y;Watanabe N;Oizumi S;Suzuki H;Ishida T;Dosaka-Akita H;Isobe H;Munakata M;Nishimura M
Notch信号在肿瘤发生中根据恶性肿瘤的类型作为癌基因或肿瘤抑制基因发挥作用。Numb抑制细胞内Notch信号传导。先前的研究已经证明Notch信号转导抑制小细胞肺癌（SCLC）细胞系的增殖。然而，在小细胞肺癌中，Notch1和Numb表达与临床病理因素或预后之间的关系仍不清楚。在这项研究中，我们评估了Notch 1和Numb在SCLC中的表达。我们对2003年至2013年期间在参与北海道肺癌临床研究小组试验（HOT）或福岛治愈胸部肿瘤调查小组（FIGHT）的16家机构手术切除的125例SCLC进行了化学评估。Notch1或Numb表达与各种临床病理特征之间的相关性进行了评估。Notch1表达与ECOG体力状态相关。Numb表达与年龄、性别和病理组织学（SCLC或联合SCLC）相关。细胞生物学表达的分析没有显示Notch1和Numb的表达之间的显著相关性。多因素考克斯回归分析显示，Notch 1高表达是影响小细胞肺癌预后的独立因素（hazard ratio = 0.503，P = 0.023）。Notch 1高表达与SCLC预后良好相关，而Numb表达无相关性。
Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.