[Antipruritic effects of pimecrolimus and tacrolimus].
[Antipruritic effects of pimecrolimus and tacrolimus].
复制标题
[吡美莫司和他克莫司的止痒作用]。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
T. Luger
中科院分区：
文献类型：
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作者：
S. Ständer;T. Luger
局部钙调神经磷酸酶抑制剂的开发显着改善了特应性皮炎等炎症性皮肤病的治疗。此外，可观察到瘙痒的显著改善。其他瘙痒性皮肤病，如慢性刺激性手部皮炎、红斑痤疮、移植物抗宿主病、肾瘙痒症、硬化性苔藓、单纯性荨麻疹、结节性荨麻疹、阴囊湿疹和反相银屑病也已成功地用吡美莫司和他克莫司治疗。目前认为其抗炎作用与抑制炎性细胞因子有关。此外，最近的研究表明，从感觉神经纤维释放神经肽和肥大细胞脱粒的吡美莫司和他克莫司介导的。在辣椒素治疗期间也观察到类似的效果。这些发现可能为最初观察到的钙调磷酸酶抑制剂相关副作用（如烧灼感和瘙痒症）提供了可能的解释。此外，抗瘙痒效力可能与对神经纤维的直接作用有关，导致抑制由未知机制介导的瘙痒。
The development of topical calcineurin inhibitors resulted in a significant improvement in the treatment of inflammatory skin diseases such as atopic dermatitis. In addition, an excellent amelioration of pruritus could be observed. Other itchy dermatoses such as chronic irritative hand dermatitis, rosacea, graft-versus-host-disease, renal pruritus, lichen sclerosus, prurigo simplex, prurigo nodularis, scrotal eczema, and inverse psoriasis also have been treated successfully with pimecrolimus and tacrolimus. The antipruritic effect currently is believed to be related to the inhibition of inflammatory cytokines. Furthermore, recent investigations indicate a release of neuropeptides from sensory nerve fibers and degranulation of mast cells mediated by pimecrolimus and tacrolimus. Similar effects have been observed during capsaicin treatment. These findings may provide a possible explanation for initially observed calcineurin inhibitors related side-effects such as burning and pruritus. Moreover, the antipruritic potency may be related to a direct effect on nerve fibers leading to suppression of itch mediated by unknown mechanisms.