Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction - Results From the Nagoya Acute Myocardial Infarction Study (NAMIS) -
Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction - Results From the Nagoya Acute Myocardial Infarction Study (NAMIS) -
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DOI：
10.1253/circj.cj-13-0251
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发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Morita, Yasuhiro;Maeda, Kengo;Murohara, Toyoaki
背景：低脂联素水平和高瘦素水平与心血管疾病的高发病率相关。然而，这些脂肪因子的水平与急性心肌梗死 (AMI) 后不良事件发生之间的关系仍不清楚。 方法和结果：本研究纳入了 724 名日本 AMI 受试者，他们成功接受了紧急经皮冠状动脉介入治疗 (PCI)。 AMI 发病后 7 天测量他们的血清脂联素和瘦素水平。 3 年随访期间共发生 63 起不良事件。脂联素和瘦素的水平以及瘦素与脂联素的比率与不良事件显着相关[风险比2.08（95%置信区间（CI）1.33-3.24），P=0.001；风险比0.62（95% CI 0.43-0.90），P=0.012；风险比 0.59（95% CI 0.45-0.76），P
Background: Low adiponectin levels and high leptin levels are associated with a high incidence of developing cardiovascular disease. However, the relationship between the levels of these adipokines and the development of adverse events after acute myocardial infarction (AMI) remains unclear.Methods and Results: This study enrolled 724 Japanese subjects with AMI who underwent successful emergency percutaneous coronary intervention (PCI). Their serum adiponectin and leptin levels were measured 7 days after AMI onset. There were 63 adverse events during the 3-year follow-up. The levels of adiponectin and leptin and the leptin to adiponectin ratio, were significantly associated with adverse events [hazard ratio 2.08 (95% confidence interval (CI) 1.33-3.24), P=0.001; hazard ratio 0.62 (95% CI 0.43-0.90), P=0.012; hazard ratio 0.59 (95% CI 0.45-0.76), P