FOXO transcription factors: key regulators of cellular quality control.
FOXO transcription factors: key regulators of cellular quality control.
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DOI：
10.1016/j.tibs.2014.02.003
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发表时间：
2014-04
影响因子：
13.8
通讯作者：
Brunet A
中科院分区：
文献类型：
--
作者：
Webb AE;Brunet A
FOXO 转录因子是胰岛素信号下游长寿的保守调节因子。这些转录因子整合营养剥夺和应激刺激发出的信号，以协调参与细胞代谢和氧化应激抵抗的基因程序。在这里，我们讨论了 FOXO 因子在促进自噬和泛素蛋白酶体系统相关基因表达中发挥关键作用的新证据，这两个细胞清除过程对于维持细胞器和蛋白质稳态（蛋白质稳态）至关重要。 FOXO 维持细胞质量控制的能力似乎对于受损蛋白质和细胞器积累的过程和病理（包括衰老和神经退行性疾病）至关重要。
FOXO transcription factors are conserved regulators of longevity downstream of insulin signaling. These transcription factors integrate signals emanating from nutrient deprivation and stress stimuli to coordinate programs of genes involved in cellular metabolism and resistance to oxidative stress. Here we discuss emerging evidence for a pivotal role of FOXO factors in promoting the expression of genes involved in autophagy and the ubiquitin-proteasome system – two cell clearance processes that are essential for maintaining organelle and protein homeostasis (proteostasis). The ability of FOXO to maintain cellular quality control appears to be critical in processes and pathologies where damaged proteins and organelles accumulate, including aging and neurodegenerative diseases.