Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India
Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India
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DOI：
10.1086/368357
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发表时间：
2003-05-15
影响因子：
6.4
通讯作者：
Mehendale, SM
中科院分区：
文献类型：
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作者：
Reynolds, SJ;Risbud, AR;Mehendale, SM
为了估计流行和意外的2型单纯疱疹病毒（HSV-2）感染对1型人类免疫缺陷病毒（HIV-1）获得的影响，在印度浦那的3家性传播感染诊所和1家生殖道感染诊所，对2732名HIV-1血清阴性患者的血清样本进行了HSV-2特异性抗体筛查。2型单纯疱疹病毒感染事件在血清学上被定义为“近期”，如果在过去6个月内可以记录到2型单纯疱疹病毒检测的阴性结果；如果自上次检测结果阴性以来已过去16个月，则定义为“远程”。入组时HSV-2的患病率为43%。2型单纯疱疹病毒的发病率为11.4例/100人年，1型单纯疱疹病毒的发病率为5.8例/100人年。2型单纯疱疹病毒感染后感染HIV-1的校正风险比为：流行的2型单纯疱疹病毒感染后感染HIV-1的风险比为1.67，遥远的2型单纯疱疹病毒感染后感染的风险比为1.92，最近的2型单纯疱疹病毒感染后感染的风险比为3.81。在本研究中，近期发生的HSV-2感染与HIV-1的最高风险相关，这表明预防HSV-2感染可能降低HIV-1获得的风险。
To estimate the impact of prevalent and incident herpes simplex virus type 2 (HSV-2) infection on the acquisition of human immunodeficiency virus type 1 (HIV-1), stored serum samples from a cohort of 2732 HIV-1 -seronegative patients attending 3 sexually transmitted infection clinics and 1 reproductive tract infection clinic in Pune, India, were screened for HSV-2 -specific antibodies. Incident HSV-2 infection was defined serologically as "recent" if a negative result of testing for HSV-2 could be documented within the previous 6 months or "remote" if 16 months had elapsed since the last negative test result. The prevalence of HSV-2 at enrollment was 43%. The HSV-2 incidence was 11.4 cases/100 person-years, and the HIV-1 incidence was 5.8 cases/100 person-years. The adjusted hazard ratios of HIV-1 acquisition from exposure to HSV-2 infection were 1.67 for prevalent HSV-2, 1.92 for remote incident HSV-2, and 3.81 for recent incident HSV-2. Recent incident HSV-2 infection was associated with the highest risk of HIV-1 in this study, which suggests that prevention of HSV-2 infection may reduce the risk of HIV-1 acquisition.