Traction Bronchiectasis/Bronchiolectasis in Interstitial Lung Abnormality: Follow-up in the COPDGene Study.
Traction Bronchiectasis/Bronchiolectasis in Interstitial Lung Abnormality: Follow-up in the COPDGene Study.
复制标题
间质性肺异常中的牵引性支气管扩张/支气管扩张：COPD基因研究的后续行动。
DOI：
10.1164/rccm.202211-2061le
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发表时间：
2023
影响因子：
24.7
通讯作者：
Hatabu,Hiroto
中科院分区：
文献类型：
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作者：
Hata,Akinori;Hino,Takuya;Li,Yi;Johkoh,Takeshi;Christiani,DavidC;Lynch,DavidA;Cho,MichaelH;Silverman,EdwinK;Hunninghake,GaryM;Hatabu,Hiroto
方法本研究分析了 COPDGene 研究中前瞻性收集的数据 (5)。所有参与者均提供了书面知情同意书。原始队列包括 10,198 名基线参与者（第一阶段：2008-2012 年）。在本研究中，我们检查了前 5,000 名 COPDGene 参与者，他们返回进行 5 年随访（第 2 阶段：2012-2016 年）。其中，有 4,684 份基线和 4,538 份后续胸部 CT 扫描可用，并使用顺序读取方法评估了 ILA (4, 5)。基线时 6% (301/4,684) 的扫描中存在 ILA，随访时 12% (551/4,538) 中存在 ILA。共有 633 名参与者在两个阶段中的一个或两个阶段接受了 ILA，并被纳入本研究。
MethodsThis study analyzed the prospectively collected data from the COPDGene study (5). All participants provided written informed consent. The original cohort included 10,198 participants at baseline (Phase 1: 2008–2012). In the present study, we examined the first 5,000 COPDGene participants who returned for 5-year follow-up visits (Phase 2: 2012–2016). Among them, 4,684 baseline and 4,538 follow-up chest CT scans were available and assessed for ILAs using a sequential reading method (4, 5). ILAs were present in 6% of the scans (301/4,684) at baseline and in 12%(551/4,538) at follow-up. A total of 633 participants presented with ILAs at either or both of the two phases and were included in this study.