Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
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DOI：
10.1016/s0092-8674(00)81569-x
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发表时间：
1998-04-17
期刊：
影响因子：
64.5
通讯作者：
Boyle, WJ
中科院分区：
文献类型：
--
作者：
Lacey, DL;Timms, E;Boyle, WJ
骨保护素的配体已经确定，它是一种与tnf相关的细胞因子，在体外破骨细胞共培养模型中取代了对基质细胞、维生素D3和糖皮质激素的需求。OPG配体（OPGL）结合一种独特的造血祖细胞，该细胞致力于破骨细胞谱系，并刺激快速诱导破骨细胞发育的基因。OPGL直接激活体外分离的成熟破骨细胞，短期给药于正常成年小鼠可导致与全身高钙血症相关的破骨细胞激活。这些数据表明OPGL是一种破骨细胞分化和激活因子。OPGL的作用在体内和体外均被OPG阻断，提示OPGL和OPG是破骨细胞发育的关键细胞外调节因子。
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and shortterm administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development.