The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder
The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder
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DOI：
10.1159/000353613
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发表时间：
2013-01-01
影响因子：
3.2
通讯作者：
Tsai, Shang-Ying
中科院分区：
文献类型：
--
作者：
Chung, Kuo-Hsuan;Huang, Shou-Hung;Tsai, Shang-Ying
目的：C-反应蛋白（CRP）是一种潜在的低度炎症标志物，与双相情感障碍的病理生理学有关。此外，双相情感障碍可能伴有功能或结构性脑改变。我们试图发现血清高敏C反应蛋白（hs-CRP）水平是否与特定脑区的结构体积变化沿着认知能力有关。研究方法：我们招募了17名身体健康的双相I型障碍（DSM-IV）患者，年龄18-45岁，情绪正常，接受威斯康星州卡片分类测试（WCST）和1.5 T的容积磁共振成像。分析方法基于隐马尔可夫随机场模型和期望最大化算法，每个脑区域的体积以占颅内总体积的百分比表示。结果如下：校正年龄和性别后，各区域中仅眶额皮质与血清hs-CRP水平呈显著负相关（左、右眶额皮质：分别为r =-0.62，p < 0.01和r =-0.67，p < 0.005）。关于认知功能，WCST表现不佳也与眶额皮质的某些亚区域有关。结论：血清hs-CRP水平升高，炎症指标，可能与眶额皮质体积减少。双相情感障碍正常期的持续性炎症可能涉及额叶通路改变的发病机制或病理生理学。版权所有（C）2013 S. Karger AG，巴塞尔
Objective: C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) levels are linked to the structural volume change of a specific brain region along with cognitive performance. Methods: We recruited 17 physically healthy patients with bipolar I disorder (DSM-IV), aged 18-45 years and euthymic, to undergo the Wisconsin Card Sorting Test (WCST) and volumetric magnetic resonance imaging at 1.5 T. The analytic method was based on the hidden Markov random field model with an expectation-maximization algorithm, and the volume of each brain region was presented as a percentage of the total intracranial volume. Results: Among the various regions, only the orbitofrontal cortex had a significantly negative correlation with serum hs-CRP levels after adjustment for age and gender (left and right orbitofrontal cortex: r = -0.62, p < 0.01, and r = -0.67, p < 0.005, respectively). Regarding cognitive function, poor WCST performance was also associated with certain subregions of the orbitofrontal cortex. Conclusion: Elevation of serum hs-CRP levels, an indicator of inflammation, may be associated with reduced volume of the orbitofrontal cortex. Persistent inflammation in the euthymic phase of bipolar disorder may involve the pathogenesis or pathophysiology of alteration of the frontal pathway. Copyright (C) 2013 S. Karger AG, Basel