Manipulation of herpes simplex virus type 1 by dielectrophoresis
Manipulation of herpes simplex virus type 1 by dielectrophoresis
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DOI：
10.1016/s0304-4165(98)00058-0
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发表时间：
1998-09-16
影响因子：
3
通讯作者：
Pethig, R
中科院分区：
文献类型：
--
作者：
Hughes, MP;Morgan, H;Pethig, R
频率依赖性介电电泳行为的包膜哺乳动物病毒，单纯疱疹病毒1型。它表明，在10 kHz-20 MHz的范围内，这些病毒颗粒，当悬浮在电导率为5 mS m（-1）的水介质中时，可以通过使用微加工电极阵列的正负介电电泳来操纵。在4.5 MHz左右的频率下观察到的从正向负向介电泳的转变与病毒作为被绝缘膜包围的导电颗粒的简单模型定性一致。(C)1998 Elsevier Science B. V.保留所有权利。
The frequency-dependent dielectrophoretic behaviour of an enveloped mammalian virus, herpes simplex virus type 1 is described. It is demonstrated that over the range 10 kHz-20 MHz, these viral particles, when suspended in an aqueous medium of conductivity 5 mS m(-1), can be manipulated by both positive and negative dielectrophoresis using microfabricated electrode arrays. The observed transition from positive to negative dielectrophoresis at frequencies around 4.5 MHz is in qualitative agreement with a simple model of the virus as a conducting particle surrounded by an insulating membrane. (C) 1998 Elsevier Science B.V. All rights reserved.