Congenital Cytomegalovirus Infection: Clinical Outcome
Congenital Cytomegalovirus Infection: Clinical Outcome
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DOI：
10.1093/cid/cit629
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发表时间：
2013-12-15
影响因子：
11.8
通讯作者：
Fowler, Karen B.
中科院分区：
文献类型：
--
作者：
Boppana, Suresh B.;Ross, Shannon A.;Fowler, Karen B.
先天性巨细胞病毒（CMV）感染是世界范围内儿童听力损失和神经功能障碍的主要原因。出生时有症状的先天性CMV感染的婴儿发生不良长期结局的风险显著增加。绝大多数先天性CMV感染的婴儿在出生时没有临床表现（无症状婴儿），这些儿童中约有10%-15%会出现长期后遗症。目前，无症状先天性巨细胞病毒感染的不良结局的预测因素尚不清楚，重要的是未来的研究解决这个问题。
Congenital cytomegalovirus (CMV) infection is a leading cause of hearing loss and neurologic disabilities in children worldwide. Infants with symptomatic congenital CMV infection at birth are at significantly increased risk for developing adverse long-term outcomes. The vast majority of infants with congenital CMV infection have no clinical findings at birth (asymptomatic infants), and about 10%-15% of these children develop long-term sequelae. Currently, predictors of adverse outcome in asymptomatic congenital CMV infection are not known, and it is important that future studies address this issue.