MONOCLONAL-ANTIBODIES AGAINST HEPATITIS-A VIRUS
MONOCLONAL-ANTIBODIES AGAINST HEPATITIS-A VIRUS
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DOI：
10.1128/jcm.18.5.1237-1243.1983
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发表时间：
1983-01-01
影响因子：
9.4
通讯作者：
GUST, ID
中科院分区：
文献类型：
--
作者：
MACGREGOR, A;KORNITSCHUK, M;GUST, ID
制备了三种抗甲型肝炎病毒的IgG2a类单克隆抗体（K2 - 4F2、K3 - 2F2和K3 - 4C8）。这些抗体的特异性通过免疫电镜、固相放射免疫分析和体外细胞培养中和试验证实。结合研究表明，它们都识别密切相关的抗原决定簇。这些单克隆抗体应被证明是诊断和研究试剂的巨大价值。
Three monoclonal antibodies (K2-4F2, K3-2F2 and K3-4C8) of the IgG2a class were raised against hepatitis A virus. The specificity of these antibodies was confirmed by immune electron microscopy, solid-phase radioimmunoassay and in vitro neutralization in cell culture. Binding studies suggested that they all recognize closely related antigenic determinants. These monoclonal antibodies should prove to be of great value as diagnostic and research reagents.