Quantitative comparisons on hand motor functional areas determined by resting state and task BOLD fMRI and anatomical MRI for pre-surgical planning of patients with brain tumors.
Quantitative comparisons on hand motor functional areas determined by resting state and task BOLD fMRI and anatomical MRI for pre-surgical planning of patients with brain tumors.
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DOI：
10.1016/j.nicl.2016.03.003
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Carpenter JS
中科院分区：
文献类型：
--
作者：
Hou BL;Bhatia S;Carpenter JS
对于术前规划，我们提出了定量比较的位置确定右手手指敲击BOLD功能磁共振成像，静息状态BOLD功能磁共振成像，并在解剖学上使用高分辨率T1加权图像的手运动功能区。数据来自10名健康受试者和25名左侧脑肿瘤患者。我们的结果表明，在位置上存在重要差异（即，> 20 mm）。这可能会对这些患者的术前计划产生重大影响，具体取决于所使用的方式。在25例病例中的13例（即，52%）的任务确定的和rs-fMRI确定的手区域之间的距离大于20 mm;在25个病例中的13个（即，52%）的任务确定的和解剖学确定的手区域之间的距离> 20 mm;并且在25个病例中的16个（即，rs-fMRI测量的手区与解剖学测量的手区之间的距离大于20 mm者占64%。只有三个案例中，所有三种方式确定的距离彼此在20 mm以内。由这三种MR方法确定的手部运动区域的位置或指纹的差异是由于这三种模式的不同潜在机制以及肿瘤对这些模式的影响。
For pre-surgical planning we present quantitative comparison of the location of the hand motor functional area determined by right hand finger tapping BOLD fMRI, resting state BOLD fMRI, and anatomically using high resolution T1 weighted images. Data were obtained on 10 healthy subjects and 25 patients with left sided brain tumors. Our results show that there are important differences in the locations (i.e., > 20 mm) of the determined hand motor voxels by these three MR imaging methods. This can have significant effect on the pre-surgical planning of these patients depending on the modality used. In 13 of the 25 cases (i.e., 52%) the distances between the task-determined and the rs-fMRI determined hand areas were more than 20 mm; in 13 of 25 cases (i.e., 52%) the distances between the task-determined and anatomically determined hand areas were > 20 mm; and in 16 of 25 cases (i.e., 64%) the distances between the rs-fMRI determined and anatomically determined hand areas were more than 20 mm. In just three cases, the distances determined by all three modalities were within 20 mm of each other. The differences in the location or fingerprint of the hand motor areas, as determined by these three MR methods result from the different underlying mechanisms of these three modalities and possibly the effects of tumors on these modalities.