Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta.
Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta.
复制标题
下丘脑神经元组胺调节白细胞介素 1 β 诱导的生理反应。
DOI：
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发表时间：
1995
影响因子：
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通讯作者：
T. Sakata
中科院分区：
文献类型：
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作者：
M. Kang;H. Yoshimatsu;S. Chiba;M. Kurokawa;R. Ogawa;Y. Tamari;M. Tatsukawa;T. Sakata
本实验观察了下丘脑组胺在大鼠摄食行为和白细胞介素1 β（IL-1 β）诱导的产热中的动态变化。腹膜内注射0.12 nmol/大鼠IL-1 β可减少食物和水的摄入量，并升高体温。然而，通过腹腔注射160 mumol/大鼠α-氟甲基组氨酸（组氨酸脱羧酶（HDC）的自杀抑制剂）诱导的神经元组胺耗竭减弱了IL-1 β对摄食的抑制作用，促进了对饮水的抑制作用，并增强了对直肠温度的升高作用。腹腔注射0.12 nmol/rat IL-1 β增加下丘脑组胺转换率。相同剂量的IL-1 β也增加HDC和组胺-N-甲基转移酶（HMT）的活性。提示IL-1 β可能通过激活HDC刺激下丘脑突触前末梢组胺的合成和释放，并通过激活MHT促进细胞外组胺的降解。下丘脑组胺动力学的这些变化调节IL-1 β诱导的摄食行为和体温。
Dynamic involvement of hypothalamic histamine in ingestive behavior and thermogenesis induced by interleukin-1 beta (IL-1 beta) was examined in rats. Intraperitoneal injection of 0.12 nmol/rat IL-1 beta decreased food and water intake and elevated body temperature. However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature. Intraperitoneal injection of 0.12 nmol/rat IL-1 beta increased hypothalamic histamine turnover rate. The same dose of IL-1 beta also increased activity of HDC and histamine-N-methyltransferase (HMT). These results suggest that IL-1 beta may stimulate synthesis and release of hypothalamic histamine in presynaptic terminals by activation of HDC and facilitate degradation of extracellular histamine by activation of MHT. These changes in the dynamics of hypothalamic histamine modulate IL-1 beta-induced ingestive behavior and body temperature.