Role of T lymphocytes and cytokines in coccidiosis
Role of T lymphocytes and cytokines in coccidiosis
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DOI：
10.1016/s0020-7519(98)00075-7
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发表时间：
1998-07-01
影响因子：
4
通讯作者：
Lillehoj, HS
中科院分区：
文献类型：
--
作者：
Lillehoj, HS
由于对宿主免疫系统的各种组成部分缺乏了解，导致保护性免疫，禽球虫病疫苗的开发受到阻碍。对小鼠细胞因子产生中细胞二分法的清楚理解和免疫试剂的可用性以及基因敲除小鼠，现在使得在该物种中进行深入的免疫学研究成为可能。通过对小鼠各种寄生虫感染模型的研究，越来越清楚的是，宿主免疫中涉及细胞因子的复杂调节。此外，在小鼠中的研究清楚地表明了涉及T淋巴细胞、巨噬细胞、自然杀伤（NK）细胞和细胞因子的各种效应机制在抗球虫病中的重要作用。在鸡球虫病的比较研究中，体内和体外研究表明，艾美耳球虫感染后会诱导产生干扰素-γ、肿瘤坏死因子和转化生长因子-β。耗竭研究揭示了CD 8（+）TCR α β（+）T淋巴细胞在宿主对禽球虫病的保护性免疫中的重要性。总之，在小鼠和鸡中的研究提供了对控制对艾美耳球虫寄生虫的免疫应答的效应细胞和可溶性因子的作用的更好理解。出版社：Elsevier Science Ltd
Development of a vaccine for avian coccidiosis has been hampered by lack of understanding of the various components of the host immune system leading to protective immunity. Clear understanding of the cellular dichotomy in cytokine production in mice and the availability of immunological reagents, as well as gene knock-out mice, now makes in-depth immunological study in this species feasible. From studies of various parasitic infection models in mice, it is becoming clear that complex regulation by cytokines is involved in host immunity. Furthermore, the studies in mice clearly indicated an important role of various effector mechanisms involving T lymphocytes, macrophages, natural killer (NK) cells and cytokines in resistance to coccidiosis. In comparative studies of coccidiosis in chickens, in-vivo and in-vitro studies revealed that interferon-gamma, tumour necrosis factor and transforming growth factor-beta are induced following Eimeria infection. Depletion studies revealed the importance of CD8(+)TCR alpha beta(+) T lymphocytes in host protective immunity to avian coccidiosis. Taken together, studies in mice and chickens are providing a better understanding of the role of effector cells and soluble factors which control immune responses to Eimeria parasites. Published by Elsevier Science Ltd.