The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis.
The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis.
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DOI：
10.1186/bcr2578
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kuperwasser C
中科院分区：
文献类型：
--
作者：
McCready J;Arendt LM;Rudnick JA;Kuperwasser C
乳腺癌是一种异质性疾病，其预后根据诊断时乳腺组织的发育阶段而变化。值得注意的是，与绝经后诊断的乳腺癌相比，与妊娠相关的乳腺癌的转移率更高，长期生存率更差。然而，与非肥胖个体中诊断出的乳腺癌相比，与肥胖相关的绝经后乳腺癌表现出更具侵袭性的行为，并导致患者的总体生存率降低。由于乳腺是一种动态组织，在女性一生中会经历显着的变化，尤其是在怀孕期间和绝经后，因此我们提出的证据支持这样的观点，即乳腺间质室内发育过程中发生的变化可能解释了乳腺癌亚型和行为的一些生物学差异。
Breast cancer is a heterogeneous disease whose prognosis varies depending upon the developmental stage of the breast tissue at diagnosis. Notably, breast cancers associated with pregnancy exhibit increased rates of metastasis and poorer long-term survival compared to those diagnosed after menopause. However, postmenopausal breast cancers associated with obesity exhibit a more aggressive behavior and confer decreased overall patient survival compared to those diagnosed in non-obese individuals. Since the mammary gland is a dynamic tissue that undergoes significant changes throughout a woman's lifetime, especially during pregnancy and following menopause, we present evidence to support the notion that changes occurring throughout development within the mammary stromal compartment may account for some of the biological differences in breast cancer subtypes and behaviors.
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影响因子：
6.2
作者：
COLDITZ, GA
通讯作者：
COLDITZ, GA
影响因子：
50.5
作者：
Berclaz, G;Li, S;International Breast Cancer Study Grp
通讯作者：
International Breast Cancer Study Grp
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
影响因子：
--
作者：
D'Cruz, CM;Moody, SE;Chodosh, LA
通讯作者：
Chodosh, LA
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ