A structured exercise program for patients with advanced non-small cell lung cancer.
A structured exercise program for patients with advanced non-small cell lung cancer.
复制标题
针对晚期非小细胞肺癌患者的结构化锻炼计划。
DOI：
10.1097/jto.0b013e31819d18e5
复制
发表时间：
2009-05
影响因子：
20.4
通讯作者：
Smith, Matthew R.
中科院分区：
文献类型：
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作者：
Temel, Jennifer S.;Greer, Joseph A.;Goldberg, Sarah;Vogel, Paula Downes;Sullivan, Michael;Pirl, William F.;Lynch, Thomas J.;Christiani, David C.;Smith, Matthew R.
运动可以改善某些癌症人群的功能结果和症状，但肺癌患者进行结构化运动的可行性，有效性和安全性尚不清楚。在这项研究中，我们研究了以医院为基础的运动计划对晚期非小细胞肺癌患者的可行性。本研究纳入了新诊断的晚期非小细胞肺癌患者，东部肿瘤协作组体能状态评分为0-1。物理治疗师在8周的时间内促进每周两次的有氧运动和重量训练。主要终点是干预的可行性，定义为坚持锻炼计划。次要终点包括通过6分钟步行试验和肌肉力量测量的功能能力，以及通过癌症治疗功能评估-肺和癌症治疗功能评估-疲劳量表测量的生活质量、肺癌症状和疲劳。2004年10月至2007年8月期间，有25名患者参加了该研究。所有参与者在研究期间接受抗癌治疗。20例患者（80%）接受了基线物理治疗评价。11名患者（44%）完成了所有16次治疗。另外6例患者参加了至少6次会议（范围，6-15），2例患者仅参加了一次会议。研究完成者的肺癌症状显著减轻，6分钟步行试验或肌肉力量没有恶化。虽然大多数参与者尝试了锻炼计划，但只有不到一半的人能够完成干预。那些完成该计划的人经历了肺癌症状的改善。基于社区或简短的运动干预可能是更可行的，在这一人群。
Exercise improves functional outcome and symptoms for certain cancer populations, but the feasibility, efficacy, and safety of structured exercise in patients with lung cancer is unknown. In this study, we examined the feasibility of a hospital-based exercise program for patients with advanced non-small cell lung cancer. This study included patients with newly diagnosed advanced stage non-small cell lung cancer and Eastern Cooperative Oncology Group performance status 0–1. A physical therapist facilitated twice-weekly sessions of aerobic exercise and weight training over an 8-week period. The primary end point was feasibility of the intervention, defined as adherence to the exercise program. Secondary endpoints included functional capacity, measured by the 6-minute walk test and muscle strength, as well as quality of life, lung cancer symptoms and fatigue, measured by the Functional Assessment of Cancer Therapy-lung and Functional Assessment of Cancer Therapy-fatigue scales. Between October 2004 and August 2007, 25 patients enrolled in the study. All participants received anticancer therapy during the study period. Twenty patients (80%) underwent the baseline physical therapy evaluation. Eleven patients (44%) completed all 16 sessions. An additional 6 patients attended at least 6 sessions (range, 6–15), and 2 patients only attended one session. Study completers experienced a significant reduction in lung cancer symptoms and no deterioration in their 6-minute walk test or muscle strength. Although the majority of participants attempted the exercise program, less than half were able to complete the intervention. Those who completed the program experienced an improvement in their lung cancer symptoms. Community-based or briefer exercise interventions may be more feasible in this population.