CD28 expression in T cell aging and human longevity
CD28 expression in T cell aging and human longevity
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DOI：
10.1016/s0531-5565(97)00132-0
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发表时间：
1998-05-01
影响因子：
3.9
通讯作者：
Schachter, F
中科院分区：
文献类型：
--
作者：
Boucher, N;Dufeu-Duchesne, T;Schachter, F
免疫系统的功能衰退对衰老和与年龄有关的疾病有重大贡献。在这里，我们进一步描述了以前在百岁老人中发现的CD 28阳性T细胞比例下降的特征。97名百岁老人、40名70-90岁的受试者（ELD组）和40名年轻人（40岁以下）的队列进行了T细胞表面CD 28、CD 4和CD 8抗原表达的表型分析。表达CD 28的T细胞的显著下降（成人与ELD或百岁老人之间的比较p < 10（-4））优先影响T细胞的CD 8（+）亚群。这种下降在很大程度上解释了与年龄相关的T细胞对促有丝分裂信号的反应性降低。CD 28的表达是调制在T细胞培养物中的生长相关的方式，这种调制是抑制在文化从centenarians.We建议，在CD 28表达的减少反映了在面对慢性刺激老化过程中的免疫系统的代偿性适应。(C)1998 Elsevier-Science Inc.
Functional decrements of the immune system have a major contribution to aging and age-related diseases. Here, we further characterize the decline in proportion of CD28-positive T cells previously identified in centenarians. Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens. The significant decline in T cells expressing CD28 (p < 10(-4) for comparisons between adults and either ELD or centenarians) affects preferentially the CD8(+) subset of T cells. This decline accounts largely for the age-related diminution of T cell responsiveness to mitogenic signals. CD28 expression is modulated in T cell cultures in a growth-related fashion and this modulation is dampened in cultures from centenarians.We propose that the decrease in CD28 expression reflects a compensatory adaptation of the immune system during aging in the face of chronic stimulation. (C) 1998 Elsevier-Science Inc.