Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study
Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study
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DOI：
10.3390/nu12061605
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发表时间：
2020-06-01
期刊：
影响因子：
5.9
通讯作者：
Wakai, Kenji
中科院分区：
文献类型：
--
作者：
Arisawa, Kokichi;Katsuura-Kamano, Sakurako;Wakai, Kenji
膳食酸负荷与代谢综合征（MetS）之间的关系尚未得到充分研究。一项横断面研究对14042名男性和14105名女性（35-69岁）进行了研究，他们参加了日本多机构合作队列研究的基线调查。使用净内源性产酸（NEAP）评分评估膳食酸负荷，该评分与肾脏净酸排泄率密切相关。根据2009年联合中期声明标准，使用身体质量指数代替腰围诊断MetS。在对潜在混杂因素进行校正后，较高的NEAP评分与MetS、肥胖、高血压和高血糖的比值比（OR）显著增加相关。在进一步调整碳水化合物摄入量或与MetS显著相关的两种营养模式评分后，这些关联仍然显著。在对纤维、铁、钾和维生素模式得分进行调整后，NEAP得分最高的四分位数相对于最低四分位数的met的OR为1.25（95%置信区间为1.12-1.39）。性别、年龄或身体质量指数与NEAP之间没有显著的相互作用。较高的膳食酸负荷与较高的MetS患病率及其若干组成部分相关，与碳水化合物摄入量或营养模式无关。
The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.