Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
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DOI：
10.1016/j.bmcl.2006.02.021
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发表时间：
2006-06
影响因子：
2.7
通讯作者：
H. Sano;T. Noguchi;A. Miyajima;Y. Hashimoto;H. Miyachi
中科院分区：
文献类型：
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作者：
H. Sano;T. Noguchi;A. Miyajima;Y. Hashimoto;H. Miyachi
吲哚和吲哚啉型碱性考克斯-1-选择性竞争性抑制剂5-氨基-1-（3，5-二甲基苯甲酰基）-1H-吲哚（1）和5-氨基-1-（3，5-二甲基苯基）-2，3-二氢-1H-吲哚（2）被发现具有抗血管生成活性，通过使用人脐静脉内皮细胞（HUVEC）进行的管形成抑制评估。
Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).